化疗后T细胞免疫缺陷与重建  

T cell lmmunodeficiency and reconstitution following chemotherapy

作　　者：顾俊[1] 陈梅[1] 

机构地区：[1]上海市杨浦区中心医院,200090

出　　处：《国际免疫学杂志》2014年第3期191-195,共5页International Journal of Immunology

基　　金：上海市卫生和计划生育委员会委级科研项目（20134443）

摘　　要：目前化疗仍是肿瘤治疗的重要的方法和手段。但是由于化疗的细胞毒性，肿瘤患者化疔后会出现不同程度的T细胞免疫缺陷，除T细胞数量的改变，T细胞功能及亚群构成也受到影响。儿童与成人受影响程度不同，儿童肿瘤患者化疗后T细胞免疫缺陷程度相对较轻。化疗后T细胞免疫重建途径主要有胸腺依赖T细胞发育途径，非胸腺依赖T细胞扩增途径以及次要的胸腺外T细胞发育途径。而且免疫重建受年龄、化疗及疾病等多方面因素影响。所以了解化疗后T细胞免疫缺陷及重建特点，对于采取干预措施改善肿瘤预后有着重要意义。So far, chemotherapy is still an important treatment for tumor. However, the cytotoxicity of chemotherapy always leads to some degree of T-cell immunodeficiency, changing the number, function and subsets of T cells. The severity of T-cell immunodeficiency is different between adults and children. Children seem relatively less affected. The pathways of T-cell immune reconstitution are mainly thymic-dependent, thymic-independent, as well as minor extrathymic T-cell lymphopoiesis. Recovery of T lymphocytes is influenced by multiple factors as age, chemotherapy and the clinical status of patients. It is important to understand T-cell immune deficiency and reconstitution for improving the prognosis of patients.

关 键 词：化疗 T细胞 免疫缺陷 免疫重建 

分 类 号：R730.53[医药卫生—肿瘤]