转化生长因子β-1与表皮生长因子受体在非小细胞肺癌中的表达及临床意义  

Expression and clinical significance of Transforming growth factorβ-1 and epidermal growth factor receptor in patients with non-small cell lung cancer

作　　者：高媛媛[1] 侯军君 温荔媛 徐睿瑞 孙立春[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内四科,150081

出　　处：《国际免疫学杂志》2014年第3期250-254,共5页International Journal of Immunology

摘　　要：目的研究非小细胞肺癌（NSCLC）中转化生长因子β-1（TGFβ-1）与表皮生长因子受体（EGFR）蛋白的表达情况，探讨二者与NSCLC临床病理特征及患者生存的关系。方法选取114例NSCLC组织，通过常规石蜡包埋行免疫组织化学染色，检测TGFβ-1与EGFR的表达情况。并对其与NSCLC临床特征关系进行分析。结果TGFβ-1在NSCLC中的阳性表达率为48．25％。TGFβ-1的表达与NSCLC的组织学类型和EGFR的表达相关（分别为χ2=11．679，P=0．001；χ2=6．883，P=0．009），而与年龄、性别、淋巴结转移、分化程度及AJCC分期无关。EGFR的表达仅与组织学类型相关（χ2=15．497，P〈0．001），而与其它病理特征无相关性。TGFβ-1阳性表达的NSCLC有较好的生存预后，具有统计学意义（χ2=4．066，P=0．044）。在EGFR阳性表达的肺癌患者中，TGFβ-1表达阳性的患者具有较长的总生存期，具有统计学意义（χ2=5．768，P=0．016）。结论TGFβ-1可能作为NSCLC尤其是EGFR阳性表达的患者较好的预后因子可为临床判断患者的预后和进行个体化治疗提供帮助。Objective To investigate the expression epidermal growth factor receptor （EGFR） in non-small cell of transforming growth factorβ-1 （TGFβ-1） and lung cancer （NSCLC） and its relationship with tumor characteristics and survival of patients with NSCLC. Methods The expression of TGFβ-1 and EGFR in 114 NSCLC patients was evaluated by immunohistochemical technique. The relationship between patient outcome and elinical pathologic characters was studied. Results Positive immunostaining of TGFβ-1 was detected in 48.25% of NSCLC samples. TGFβ-1 expression correlated with histological type and EGFR expression （χ2 = 11. 679,P = O. 001 ;χ2 = 6. 883, P = O. 009, respectively）. The expression of TGFβ-1 was not correlated with gender, age, lymph node, differentiation and AJCC. EGFR expression significantly related with histological type（χ2 = 15. 497, P 〈 0. 001 ）, but not associated with clinicopathological features. Patients with positive TGFβ-1 expression had better prognosis （χ2 = 4. 066,P = 0. 044）. In EGFR positive patients, positive TGFβ-1 expression was favorable prognostic factor. Patients with TGFβ-1 positive expression shown longer overall surviv- al（χ2 = 5. 768, P = 0. 016）. Conclusion TGFβ-1 may be a favourable prognostic factor for the patients with NSCLC, especially for the patients with positive EGFR,the results may help to predict the prognosis and opti- mize the strategies for individualized therapy.

关 键 词：非小细胞肺癌 转化生长因子Β-1 表皮生长因子受体 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]