多层螺旋CT灌注成像在脑胶质瘤分级中的价值与微血管密度的相关性研究  

Application value of multi-slice spiral CT perfusion imaging in brain gliomas and its relation with microvessel density

作　　者：洪建斌[1] 许乃滔[1] 侯志雄[1] 

机构地区：[1]广东医学院附属西乡人民医院CT室,518102

出　　处：《检验医学与临床》2014年第9期1169-1170,共2页Laboratory Medicine and Clinic

基　　金：中国高校医学期刊临床专项资金项目(112210425)

摘　　要：目的研究多层螺旋CT(MSCT)灌注成像在脑胶质瘤(BG)分级中的价值与微血管密度(MVD)的相关性。方法选择该院2010年3月至2013年3月诊治的89例BG患者作为观察对象,根据BG分级标准分成高级别组以及低级别组。对比两组MSCT参数以及MVD、血管内皮生长因子(VEGF);分析相对脑血容量(rCBV)和MVD、VEGF的相关性。结果高级别组的脑血流量(CBF)、相对脑血流量(rCBF)、脑血容量(CBV)、rCBV均明显高于低级别组;高级别组VEGF阳性率为89.13%(41/46),明显高于低级别组的55.81%(24/43);高级别组MVD为70.76±8.85,明显高于低级别组的37.75±5.65,差异均具有统计学意义(P<0.05)。且rCBV值与MVD以及VEGF的表达均呈正相关(r分别为0.610、0.631,P<0.05)。结论 rCBV与MVD以及VEGF的表达呈正相关,MSCT可为BG分级提供较好的影像学依据。Objective To study the value of multi-slice spiral CT （MSCT ） perfusion imaging in grading of brain glioma（BG） and its correlation with microvessel density （MVD） .Methods A total of 89 BG patients ,treated in this hospital from March 2010 to March 2013 ,were enrolled and divided into high grade group and low grade group , according to the grading levels .MSCT parameters and MVD ,vascular endothelial growth factor（VEGF） levels were compared ,and the correlation between relative cerebral blood flow （rCBV） and MVD ,VEGF were analyzed .Results Levels of cerebral blood flow （CBF） ,rCBF ,cerebral blood volume（CBV） ,relative CBV（rCBV） of high grade group were significantly higher than low grade group （P〈 0 .05） .The positive rate of VEGF in high grade group was 89 .13% （41/46） ,higher than the 55 .81% （24/43） of low grade group（P〈0 .05） .Level of MVD in high grade group was 70 .76 ± 8 .85 ,significantly higher than the 37 .75 ± 5 .65 of low grade group（P〈0 .05） .rCBV level was positive-ly correlated with MVD and VEGF expression level （r= 0 .610 and r= 0 .631 ,P〈 0 .05） .Conclusion rCBV level could be positively correlated with MVD and VEGF expression level in patients wit BG .MSCT could provide fine im-aging evidence for the grading of BG .

关 键 词：多层螺旋CT灌注成像 脑胶质瘤分级 微血管密度 相关性 

分 类 号：R737.9[医药卫生—肿瘤]