含复方尿囊素四联疗法治疗幽门螺杆菌感染慢性胃炎的疗效  

Efficacy of compound allantoin containing quadruple Helicobacter pylori infection

作　　者：崔梅花[1] 魏红[1] 雷晓燕[1] 戴立娜 马志琳 

机构地区：[1]航天中心医院(北京大学航天临床医学院)消化科,北京100049

出　　处：《中华消化杂志》2014年第5期297-301,共5页Chinese Journal of Digestion

摘　　要：目的评价含复方尿囊素四联10 d疗法对H．pylori感染的慢性胃炎患者的疗效，并与含铋剂四联疗法进行比较。方法173例经胃镜证实的H．pylori阳性慢性胃炎患者，分为含尿囊素四联10 d组（43例）、含尿囊素四联24 d组（46例）、含铋剂四联10 d组（42例）和含铋剂四联24 d组（42例）。治疗结束后观察各组患者H．pylori根除率、胃肠道症状（上腹痛、腹胀、嗳气）缓解率和不良反应等。采用意向性分析和符合方案分析，行卡方检验。结果含尿囊素四联10 d组、含尿囊素四联24 d组、含铋剂四联10 d组和含铋剂四联24 d组的H．pylori根除率，行意向性分析分别为90．7％（39／43）、91．3％（42／46）、90．5％（38／42）和88．1％（37／42），行符合方案分析分别为90．7％（39／43）、93．3％（42／45）、90．5％（38／42）和90．2％（37／41），各组比较差异均无统计学意义（P均〉O．05）。治疗后10 d，含尿囊素四联24 d组和含铋剂四联24 d组的上腹痛缓解率分别为81．1％（30／37）和78．8％（26／33），腹胀缓解率分别为82．4％（28／34）和71．0％（22／31），嗳气缓解率分别为76．9％（20／26）和75．0％（21／28），两组比较差异均无统计学意义（P均〉O．05）；治疗后24 d，含尿囊素四联24 d组和含铋剂四联24 d组的上腹痛缓解率分别为91．9％（34／37）和87．9Yoo（29／33），腹胀缓解率分别为94．1％（32／34）和87．1％（27／31），嗳气缓解率分别为96．2％（25／26）和85．7％（24／28），两组比较差异均无统计学意义（P均〉O．05）。两组上腹痛和腹胀缓解率在治疗后24 d比治疗后10 d均有提高，但差异均无统计学意义（P均〉O．05），而含尿囊素四联24 d组的嗳气缓解率在治疗后24 d高于治疗后10 d，差异有统计学意义（x2=4．127，p=0．042）。各组均无严重不良反应发生，含尿囊素四�Objective To evaluate the efficacy of 10-day compound allantoin containing quadrupleregimen in the treatment of chronic gastritis with Helicobacter pylori （H. pylori） infection, and tocompare with the bismuth-containing quadruple therapy. Methods Altogether 173 patients withH. pylori positive chronic gastritis confirmed by gastric endoscope were divided into 10-day compoundallantoin containing quadruple regimen group （n = 43）, 24-day compound allantoin containing quadrupleregimen group （n = 46）, 10-day bismuth-containing quadruple regimen group （n = 42） and 24-daybismuth-containing quadruple regimen group （n = 42）. After the treatment, the eradication rate ofH. pylori, the rate of gastrointestinal symptoms （epigastric pain, bloating and belching） relief and theadverse effects of each group were observed. Intention-to-treat （ITT）, per-protocol （PP） statisticalanalysis and chi-square analysis were performed for statistical analysis. Results H. pylori eradicationrates of 10-day compound allantoin containing quadruple regimen group, 24-day compound allantoin containing quadruple regimen group, 10-day bismuth-containing quadruple regimen group and 24-day bismuth-containing quadruple regimen group analyzed by ITT were 90. 7% （39/43）, 91. 3% （42/46）, 90.5% （38/42） and 88.1%（37/42）, respectively; while analyzed by PP were 90.7% （39/43）, 93.3% （42/45）, 90.5% （38/42） and 90.2% （37/41）, respectively. And there were no statistical differences between groups （all P〉0.05）. Ten days after the treatment, the rates of epigastric pain relief of 24-day compound allantoin containing quadruple regimen group and 24-day bismuth-containing quadruple regimen group were 81.1% （30/37） and 78.8% （26/33）, respectively, the rates of bloating relief were 82.4% （28/34） and 71. 0% （22/31）, respectively, and the rates of belching relief were 76. 9% （20/26） and 75.0% （21/28）, respectively. There were no statistical differences between the two groups fall

关 键 词：尿囊素 铋 质子泵抑制剂 螺杆菌 幽门 

分 类 号：R573.3[医药卫生—消化系统]