羟基磷灰石晶须/纳米氧化锌复合抗菌人工骨体外极限降解实验  

Extreme Degradation Experiment of HAPw/n-ZnO Compound Antibacterial Artificial Bone Material in Vitro

作　　者：杨立斗[1] 孙帆 王刚[1] 袁艳波[1] 苏军[1] 张文云[1] 黄明华[3] 

机构地区：[1]成都军区昆明总医院口腔科 [2]78373部队卫生所 [3]昆明理工大学材料科学与工程学院

出　　处：《昆明医科大学学报》2014年第5期24-28,32,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(619220120058)

摘　　要：目的将纳米氧化锌对羟基磷灰石晶须进行改性,制备合成一种抗菌植骨复合材料,研究其在极限环境中的降解和物质变化.方法通过溶胶-凝胶法制备纳米氧化锌,将制备所得纳米氧化锌改性羟基磷灰石晶须,得到羟基磷灰石晶须/纳米氧化锌复合材料.依据ISO 10993-14标准,采用柠檬酸缓冲溶液浸泡测试失重率,并对材料表面的形态变化作扫描电镜观察和X射线衍射分析.结果 HAPw/n-ZnO、HAPw降解率分别为:25.44%、18.59%,浸泡后通过扫描电镜可以明显观察到断裂的羟基磷灰石晶须,其表面的纳米氧化锌颗粒大量减少.XRD分析羟基磷灰石的三强峰降低.结论 HAPw/n-ZnO属于低可溶性材料.Objective Modify hydroxyapatite whisker （HAPw） by nano zinc oxide （ZnO） to synthesize a kind of antibacterial implant bone compound material,and study its degradation and substantial changing in extreme environment.Methods Nano ZnO was prepared through sol-gel method,and modified HAPw by nano ZnO to achieve nano ZnO-HAPw compound material.According to ISO 10993-14 standards,the degradation rate of nano ZnO-HAPw was tested after soaked in citrate buffer solution,the surface morphology change was examined with by scanning electric microscope （SEM） and XRD analysis.Results The degradation rate was 25.44％ （HAPw/n-ZnO）,18.59％ （HAPw）,respectively.SEM showed apparently that HAPw fractured and the quantities of nano ZnO particles significantly reduced after soaking.XRD analysis indicated that the three strong peaks of HAPw lowered.Conclusion Nano ZnO-HAPw is a low soluble materials.

关 键 词：羟基磷灰石晶须 氧化锌 体外降解 

分 类 号：R783.1[医药卫生—口腔医学]