结缔组织生长因子与肝纤维化关系的研究进展  

Research progress on the relationship between connective tissue growth factor and hepatic fibrosis

作　　者：贾玉杰[1] 

机构地区：[1]大连医科大学基础医学院病理生理学教研室,辽宁大连116044

出　　处：《大连医科大学学报》2014年第2期103-109,共7页Journal of Dalian Medical University

基　　金：辽宁省自然科学基金资助项目(201102055);辽宁省教育厅资助项目(2009A190)

摘　　要：肝纤维化的形成是一个多因素、多细胞参与的复杂过程,近来研究发现,结缔组织生长因子对促进纤维化的发生发展起正调节作用。结缔组织生长因子是一种多功能的分泌性多肽,可以调节细胞增殖、分化以及黏附等生物学活性,在肝组织损伤修复、细胞外基质合成、临床上肝纤维化的诊断及治疗等方面发挥重要作用。The formation of hepatic fibrosis is a complicated process involving multiple factors and cells .It has been found form recent research that connective tissue growth factor plays a positive regulatory role in promoting the occurrence and development of hepatic fibrosis .Connective tissue growth factor belongs to a family of secreting polypeptide , which can regulate cell proliferation , differentiation and adherence , etc.It also plays very important roles in hepatic tissue repair , ex-tracellular matrix synthesis , diagnosis and treatment of hepatic fibrosis in clinical settings , etc.

关 键 词：结缔组织生长因子 肝纤维化 细胞外基质 肝星状细胞 

分 类 号：R575.2[医药卫生—消化系统]