老年与中青年发病的溃疡性结肠炎患者临床特点比较  

Comparison of clinical characteristics of new onset ulcerative colitis in the elderly versus the youth and middle-aged patients

作　　者：赵萍[1] 李传凤[2] 吕愈敏[2] 顾芳[2] 白鹏[2] 

机构地区：[1]北京清华大学医院内科,100084 [2] 北京大学第三医院消化科

出　　处：《中华老年医学杂志》2014年第5期503-506,共4页Chinese Journal of Geriatrics

摘　　要：目的 探讨老年和中青年发病的溃疡性结肠炎（UC）患者在临床表现、内镜、病理及治疗方法等方面的差异. 方法 对1994-2010年间北京大学第三医院住院的178例UC患者进行回顾性分析,分为老年组（≥60岁发病）27例及中青年组（＜60岁发病）151例,比较两组在临床表现、内镜、病理以及主要实验室检查、病情严重程度分型、治疗方法等方面的异同. 结果 老年组男性21例,女性6例;中青年组男性83例,女性68例,老年组中男性比率（77.8％）高于中青年组（55.0％）（P＜0.05）;两组初发型和慢性复发型的比率差异无统计学意义;老年组腹痛比率（44.4％）低于中青年组（78.8％）（P＜0.05）.肠镜下病变分级：老年组Ⅰ、Ⅱ级比率（70.4％）明显高于中青年组（39.9％）,Ⅲ～Ⅳ级比率（29.6％）明显低于中青年组（60.1％）（P＜0.05）;两组间病变范围、特征性病理表现、诱导缓解的常用药物及治疗方式差异无统计学意义（P＞0.05）. 结论 同中青年发病的UC患者比较,老年发病的UC患者中男性比率明显升高,腹痛相对少见,内镜下病变相对较轻.Objective To analyze the differences in the clinical characteristics,endoscopy,pathology and therapy between the patients with new onset ulcerative colitis（UC） in the elderly versus youth and middle-aged patients.Methods A review analysis was carried out in the 178 hospitalized patients with UC in Third Hospital of Peking University from 1994 to 2010.The patients were divided into two groups according to the age of onset：UC onset at age of 60 years and older were enrolled in elderly group; UC onset at age less than sixty years were enrolled in youth and middle-aged group.The data of clinical manifestation,endoscopy,pathology,laboratory test,the severity of disease classification and therapy were analyzed and compared between the two groups.Results The elderly group consisted of 21 men and 6 women.The youth and middle-aged group consisted of 83 men and 68 women.The ratio of male was higher in elderly group than in youth and middle-aged group （77.8% vs.55.0%,P〈0.05）.No significant difference in the clinical type of UC was observed （P〉0.05）.The ratio of abdominal pain in elderly group was lower than in youth and middle-aged group （44.4% vs.78.8%,P〈0.05）.There were no significant differences in other symptoms,laboratory test and the severity of disease between the two groups （all P〉0.05）.The ratio of Grade Ⅰ and Ⅱwas much higher in the elderly than in youth-middle-aged group（70.4% vs.39.9%,P〈0.05）,but the ratio of Grade Ⅲ and Ⅳ was much lower in the elderly than in youth-middle group（29.6% vs.60.1%,P〈0.05）.No significant differences between the two groups were found in the extent of disease,pathological characteristics and therapy （all P〉0.05）.Conclusions Compared with the youth and middle-aged patients with onset UC,the ratio of male patients was higher,the ratio of abdominal pain was lower,and the severity of endoscopic manifestation was less in the elderly patients with onset UC.

关 键 词：直肠结肠炎 

分 类 号：R574.62[医药卫生—消化系统]