以多胺代谢为靶点的抗肿瘤研究进展  

Research progress on polyamine metabolism as a target for anti-cancer therapy

作　　者：王清[1,2] 王艳林[1,2] 曹春雨[1,2] 

机构地区：[1]三峡大学医学院 [2]三峡大学分子所科级,湖北省宜昌市443002

出　　处：《中国肿瘤临床》2014年第9期597-600,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助项目(编号：81372265);三峡大学培优基金资助项目(编号：2013PY052)资助

摘　　要：肿瘤细胞的恶性增殖依赖细胞内的高多胺水平,抑制多胺合成或促进多胺分解均能够降低肿瘤细胞内的多胺水平,因此通过耗竭肿瘤细胞中的多胺含量抑制肿瘤细胞增殖成为新的抗肿瘤研究策略。本文简要综述了近年来以多胺代谢为靶点,通过多种方式耗竭肿瘤细胞内多胺的抗肿瘤研究进展。Rapid tumor cell growth depends on intracellular polyamine levels higher than those of normal cells. Intracellular polyamine depletion inhibits tumor cell proliferation and induces tumor cell apoptosis. Therefore, polyamine metabolism has recently been identified as an important target for anti-tumor therapy. This article briefly summarizes recent polyamine metabolism targeting, polyamine depletion within the tumor cells through a variety of methods, and the antitumor effects of the treatment.

关 键 词：肿瘤 多胺合成 多胺分解 多胺类似物 多胺转运 

分 类 号：R730.5[医药卫生—肿瘤]