儿童胆汁反流性胃炎与幽门螺杆菌感染的关系  

Correlation between Bile Reflux Gastritis and Helicobacter Pylori Infection in Children

作　　者：赵煜[1] 张书红[1] 刘风林[1] 李娟[1] 李妍[1] 

机构地区：[1]天津市儿童医院消化科,300074

出　　处：《天津医药》2014年第5期485-486,共2页Tianjin Medical Journal

摘　　要：目的探讨儿童胆汁反流性胃炎(BRG)与幽门螺杆菌(HP)感染之间的关系。方法 258例胆汁反流性胃炎患儿为BRG组,1 749例无胆汁反流的胃黏膜炎症患儿为对照组,根据病情分级(轻度、中度、重度)将BRG患儿分为3组,根据胆汁反流程度(Ⅰ度、Ⅱ度、Ⅲ度)将BRG患儿再分为3组,对各组间HP感染率进行分析。结果 BRG组HP感染率为46.12%(119/258),高于对照组的34.02%(595/1 749),差异有统计学意义。BRG组中病情轻度、中度和重度患者的HP感染率分别为40.86%(38/93)、45.53%(56/123)和59.52%(25/42),差异无统计学意义(χ2=4.089,P>0.05)。BRG组中按胆汁反流Ⅰ度、Ⅱ度和Ⅲ度患者的阳性率分别为37.32%(53/142)、53.68%(51/95)和71.43%(15/21),差异有统计学意义(χ2=12.022,P<0.01)。结论在儿童患者中HP感染是BRG的致病因素之一,随HP感染率增高,胆汁反流程度加重。Objective To assess the relationships between bile reflux gastritis （BRG） and Helicobacter pylori infec-tion in children. Methods A total of 258 BRG cases were included in BRG group and 1 749 gastric mucosal inflammation cases without bile reflux were used as control group. Children with BRG were divided into three groups according to the dis-ease classification and they were also sub-divided into three groups according to the bile reflux indexing. The infection rates of Helicobacter pylori were analyzed in different groups. Results Compared to control group （34.02%）, the infection rate of Helicobacter pylori was significantly higher in BRG group （46.12%）. The infection rates of Helicobacter pylori infection were 40.86%（38/93）, 45.53%（56/123） and 59.52%（25/42） in patients with mild, moderate and severe infections. There was no significant difference between them （χ2=4.089, P〉0.05）. The positive rates of Helicobacter pylori infection were 37.32%（53/142）, 53.68%（51/95） and 71.43%（15/21） in children withⅠ,ⅡandⅢreflux indexing, and there was significant differ-ence between them （χ2=12.022,P〈0.01）. Conclusion Helicobacter pylori infection is one of the causative factors leading to BRG in children. The bile regurgitation increased with the increasing of Helicobacter pylori infection.

关 键 词：胆汁反流 胃炎 螺杆菌 幽门 儿童 病情分级 反流分度 

分 类 号：R773.34[医药卫生—眼科]