Omega-3多不饱和脂肪酸抗心律失常作用及其机制研究进展  

Anti-arrhythmic effect of omega-3 polyunsaturated fatty acids and its underlying mechanism： a review of research progress

作　　者：蓝云锋[1] 李泱[2] 

机构地区：[1]解放军总医院海南分院保健科,三亚572000 [2]解放军总医院老年心血管病研究所,北京100853

出　　处：《中华老年多器官疾病杂志》2014年第4期304-308,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金（81170177）

摘　　要：越来越多的研究表明，n-3多不饱和脂肪酸（n-3PUFAs）能降低心率，提高心率变异性，减少室性心律失常的发生，预防心源性猝死及减少心房颤动复发等抗心律失常作用，也有研究发现n-3PUFAs具有致心律失常的作用。本文通过分析n-3PUFAs离子通道作用特点及其抗心律失常作用机制，发现n-3PUFAs干预方式不同，作用机制不完全一样，表明n-3PUFAs在抗心律失常方面具有两面性。Much evidence shows that omega-3 polyunsaturated fatty acids （n-3PUFAs） protect the heart by reducing heart rate, increasing heart rate variability, decreasing atrial fibrillation, and preventing ventricular fibrillation arrhythmias and sudden cardiac death. However, some researches suggest that n-3PUFAs exert pro-arrhythmic action. The purpose of this review was to summarize the effects of n-3PUFAs on ion channels and anti-arrhythmic mechanism. Acute administration and long-term use of n-3PUFAs have quite different electrophysiological actions, indicating their anti-and pro-arrhythmic actions in different clinical settings.

关 键 词：N-3多不饱和脂肪酸 抗心律失常药物 心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]