聚乳酸/辣椒素复合载药薄膜的制备及药物释放  

Preparation and Drug Releasing Behavior of PLA/Capsaicin Composite Membranes

作　　者：史雁暇[1,2] 李引乾[1] 杨帅龙 曹新宇[2] 马永梅[2] 

机构地区：[1]西北农林科技大学动物医学院,杨凌712100 [2]中国科学院化学研究所绿色印刷重点实验室,北京100190

出　　处：《材料导报》2014年第8期60-64,共5页Materials Reports

基　　金：国家自然科学基金(NSFC 51073163);国家973计划(2012CB933801)

摘　　要：利用静电纺丝法和溶液法分别制备了具有微纳米纤维结构、串珠结构和较密实结构的聚乳酸/辣椒素复合载药薄膜(分别称为薄膜Ⅰ、薄膜Ⅱ和薄膜Ⅲ)。研究了不同载药量(5%、10%和15%,质量分数)和不同微结构对药物释放行为的影响。药物释放研究表明:PLA/Cap复合载药薄膜的微结构和载药量都对药物释放行为有重要的影响。当载药量为5%和10%(质量分数)时,药物释放行为主要受载药薄膜的微结构影响,释放速度由快到慢为:薄膜I、薄膜Ⅱ、薄膜Ⅲ;随着载药量的增加药物释放速度加快,且3种载药薄膜的辣椒素释放速度之间的差别减小。当载药量达15%(质量分数)时,载药量对药物释放行为的影响较微结构的影响更加显著,3种载药薄膜的药物释放行为接近。Polylactide （PLA）/capsaicin composite membranes with nanofiber structure （mats Ⅰ）,＂bead on string＂ structure （mats Ⅱ） were prepared by electrospinning.A dense film （mats Ⅲ） was also prepared by solution casting method.The effects of microstructure and drug loading （5wt％,10wt％ and 15wt％） on the releasing rate were studied.The results show that both the microstructure and drug loading of the membrane play important roles in the releasing of capsaicin.When the drug loadings are 5wt％ or 10wt％,the order of the capsaicin release rate from fast to slow is：Mats Ⅰ ＞ Mats Ⅱ ＞ Mats Ⅲ.With the increase of capsaicin loading,the durg release rate increases,and the differences between the composite membranes decrease.When the composite membranes＇ drug loading reach 15wt％,the effect of drug loading on the drug release rate become more remarkable,and the drug release rates of the three composite membranes become more close to each other.

关 键 词：辣椒素 聚乳酸 载药 电纺 药物缓释 

分 类 号：R318.08[医药卫生—生物医学工程]