核受体PXR在宫颈鳞癌组织及SiHa细胞中的表达及临床意义  

Expression and Clinical Significance of Pregnane X Receptor in Cevical Squamous Cell Carcinoma and SiHa Cell Lines

作　　者：郑燕珊[1] 吴曼鹏 倪仰鹏[3] 陈理明[4] 程訸 徐涵[1] 牛永东[5] 

机构地区：[1]汕头大学医学院,广东汕头515041 [2]汕头市第二人民医院,广东汕头515011 [3]揭阳市人民医院,广东揭阳522000 [4]汕头大学医学院第一附属医院,广东汕头515041 [5]上海市肿瘤研究所,上海200032

出　　处：《深圳中西医结合杂志》2014年第2期5-7,14,F0003,共5页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：中国博士后科学基金资助项目(2012M510200);广东省自然科学基金资助项目(S2012010010955);广东省医学科研基金资助项目(A2013656);上海市肿瘤研究所"癌基因及相关基因国家重点实验室"开放课题(90-14-03);中央财政支持地方高校发展专项资金资助项目

摘　　要：目的:探讨核受体孕烷X受体(PXR)在宫颈鳞癌组织的表达及与宫颈鳞癌发生的关系。方法:采用免疫组织化学及细胞免疫化学检测核受体PXR在41例宫颈癌组织及宫颈鳞癌细胞株SiHa中的表达。结果:PXR在宫颈鳞癌细胞株SiHa中有表达;正常宫颈组织有PXR表达,41例宫颈鳞癌组织中PXR的阳性率为59.5%,且宫颈癌组织中明显低表达。结论:PXR的表达水平与宫颈癌的发生有一定的相关性,可能成为今后判断宫颈癌预后有价值的标志物。Objective To explore the expression of pregnane X receptor（PXR） in cervical squamous cell carcinogenesis. Methods Immunohistochemistry and cellular immunohistochemistry were utilized to assess the expression of PXR both in cervical squamous cell lines and 41 human tissue samples. Results PXR was expressed in cervical squamous cancer cells and normal cervical tissue samples. The positive rate of PXR was 59.5 % in 41 human tissue samples, and the expression levels of PXR were lower or greatly diminished in squamous cell cancer tissues compared to normal cervical tissues. Conclusion Our data showed that the expression level of PXR was related with cervical squamous cell carcinogenesis and it might be a valuable marker in the prognosis of cervical carcinogenesis.

关 键 词：PXR 宫颈鳞癌 肿瘤发生 

分 类 号：R737.9[医药卫生—肿瘤]