无症状颈动脉狭窄患者认知功能障碍的临床研究  

Cognitive impairment in asymptomatic carotid stenosis patients

作　　者：耿翔[1] 吴逸雯[2] 陈旭[1] 李钢[1] 

机构地区：[1]上海市第八人民医院神经内科,200235 [2]上海交通大学医学院附属瑞金医院神经内科

出　　处：《中华老年心脑血管病杂志》2014年第5期465-467,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨无症状颈动脉狭窄和认知功能障碍的关系。方法选取无症状颈动脉狭窄患者80例为狭窄组,另选择同期门诊体检者80例为对照组。采用中文版蒙特利尔认知评估量表(MoCA)和简易智能状态检查量表(MMSE)对2组进行认知功能评价并比较。结果 2组MMSE评分比较,差异无统计学意义(P>0.05)。与对照组比较,狭窄组MoCA总分明显降低[(24.23±1.47)分vs(27.88±1.51)分,P=0.001],高血压(21.3%vs65.0%)、糖尿病(17.5%vs 40.0%)、吸烟(11.3%vs 41.3%)、血脂异常(13.8%vs 62.5%)比例明显升高,差异有统计学意义(P<0.01)。结论无症状颈动脉狭窄患者存在认知障碍。高血压、糖尿病、吸烟和高脂血症可能促进无症状颈动脉狭窄患者的认知功能减退。Objective To study the relation between asymptomatic carotid stenosis and cognitive impairment.Methods Eighty asymptomatic carotid stenosis patients served as a carotid stenosis group and 80subjects undergoing physical examination served as a control group in this study. Their cognitive functions were assessed according to the MoCA and MMSE.Results No significant difference was found in MMSE score between the two groups（P〉0.05）.The total MoCA score was significantly lower in carotid stenosis group than in control group while the incidence of hypertension,diabetes mellitus（DM）,smoking and dyslipidemia was significantly lower in control group than in carotid stenosis group（21.3% vs 65.0%,17.5% vs 40.0%,11.3% vs 41.3%, 13.8%vs 62.5%,P〈0.01）.Conclusion Cognitive function is impaired in asymptomatic carotid stenosis patients.Hypertension,DM,smoking and dyslipidemia contribute to cognitive impairment in asymptomatic carotid stenosis patients.

关 键 词：颈动脉狭窄 认知障碍 高血压 糖尿病 吸烟 高脂血症 

分 类 号：R749.1[医药卫生—神经病学与精神病学]