多发性抽动症患儿血清S100B蛋白浓度检测及其临床意义  

Determination the serum S100B protein concentrations in children with Tourette's syndrom and its clinical significance

作　　者：阮学东[1] 叶飞[1] 郦红[1] 

机构地区：[1]绍兴市人民医院浙江大学绍兴医院儿科,浙江绍兴312000

出　　处：《中国临床药理学杂志》2014年第5期411-413,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省绍兴市科技局基金资助项目(2003167)

摘　　要：目的观察多发性抽动症患儿血清S100B蛋白与健康同龄儿童是否存在差异及其临床意义。方法选择我院收治的多发性抽动症（TS）患儿164例（病例组），同期健康儿童98例（对照组），用酶联免疫吸附法（ELISA）检测鸭患儿和健康儿童的血清S100B水平。结果正常及-Is组儿童血清S100B浓度，随年龄的增大呈现下降趋势；TS患儿血清S100B与同龄组健康儿童相比显著升高（P〈0．05）；亚组分析，3～6岁组儿童，正常组与TS组S100B差别无统计学意义（P〉0．05）；而7-10岁组，11～14岁组，差别均有统计学意义（P〈0．05）。结论血清S100B浓度呈年龄依赖型，且偈患儿水平高于同龄正常儿童。Objective To evaluate the clinical value of serum S100B protein concentrations in children with Tourette＇s syndrome （TS）. Meth- ods One hundred and sixty -four children with TS recruited from Feb 2010 to Mar 2013 in our hospital were deemed as case group. And 98 healthy children in the same period were collected from the same depart- ment for control group. All of the children in the two groups were tested for S100B level in the serum by using ELISA array. Results The serum level of S100B in healthy children and children with TS was negatively correla- ted with age which significantly decreased with age increased. There was no significance on the diference in two groups of the 3 -6 years old. There were significance on the diference in two groups both 7 - 10 years old and i I - 14 years old. The serum SI00B protein level was much higher in pa- tients with TS compared with healthy children （P 〈 0. 05）. Conclusion The serum level of S100B was associated age and much higher in TS than that of in healthy children.

关 键 词：血清S100B蛋白 多发性抽动症 发病机制 

分 类 号：R748[医药卫生—神经病学与精神病学] R977.6[医药卫生—临床医学]