血清结肠癌特异性抗原-2检测在结直肠癌随访和预后判断中的应用  

Application of serum colon cancer-specific antigen-2 in postoperative follow-up and prognostic judgment of colorectal cancer

作　　者：薛刚[1] 周均[2] 曹永宽[2] 王晓娟[1] 蒋金恒[1] 杨勇[1] 

机构地区：[1]成都军区总医院甲状腺乳腺外科,成都610083 [2]成都军区总医院普通外科,成都610083

出　　处：《重庆医科大学学报》2014年第3期354-357,共4页Journal of Chongqing Medical University

基　　金：四川省卫生厅基金资助项目(编号:080009);成都军区总医院英杰人才培训计划

摘　　要：目的：评估血清结肠癌特异性抗原-2（colon cancer-specific antigen-2, CCSA-2）检测在结直肠癌（colorectal cancer, CRC）术后随访监测和预后判断中的价值。 方法：收集49例CRC住院患者（含结肠癌14例、直肠癌35例）术前3天、术后7天的血液样本各3ml, 酶联免疫吸附法测定其中CCSA-2的含量。术后每3~6月检测血清CCSA-2含量1次，观察其含量变化与肿瘤复发转移之间的关系。 结果：术后第7天CRC患者血清中CCSA-2的含量明显较术前降低（t=26.53, P〈0.001）。肿瘤复发转移后其血清CCSA-2的含量再次升高，高于术后第7天水平（P〈0.01）。发生了复发转移者的术前血清CCSA-2含量明显高于未发生复发转移者的术前含量（t=4.94, P〈0.001）。 结论：血清CCSA-2有望成为CRC患者术后随访的一个有用的监测指标，同时也有望成为判断结直肠癌患者预后的一个血清标志物。Objective：To evaluate the value of serum colon cancer-specific antigen-2 （CCSA-2） as a surveillance and prognostic marker for eolorectal caneer（CRC）. Methods：CCSA-2 content in the serum was measured using ELISA method from 49 CRC patients（including 14 colon cancer patients and 35 rectal cancer patients） on 3 d before surgery and on 7 d after surgery,respectively. Serum CCSA-2 level was also detected every 3-6 months during the follow-up to observe the relationship between CCSA-2 level and tumor recurrence and metastasis. Results：Serum CCSA-2 content in CRC patients was significantly decreased on 7 d after surgery（t= 26.53,P〈0.001） ,but it was rebounded to a high level again when the recurrence occurred（P〈0.01）. Pre-operative serum CCSA-2 level in patients with recurrence after surgery was significantly higher than that in the patients without recurrence. Conclusion：Serum CCSA-2 may be a useful biomarker in surveillance and prognosis estimate for CRC.

关 键 词：结肠癌特异性抗原-2 结直肠癌 监测 预后 标志物 

分 类 号：R735.3[医药卫生—肿瘤]