蝙蝠葛酚性碱对胃癌细胞株SGC-7901Fas基因表达的影响  

THE EFFECTS OF PHENOLIC ALKALOIDS FROM MENISPHERMUM ON FAS OF GASTRIC CANCER CELL SGC- 7901

作　　者：章艳[1] 苏慧[1] 张淼[1] 刘松涛[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《牡丹江医学院学报》2014年第2期10-11,共2页Journal of Mudanjiang Medical University

基　　金：黑龙江省中医管理局ZHY12-2059;黑龙江中医药大学‘优秀创新人才支持计划’科研项目;黑龙江省自然基金H20139/H067

摘　　要：目的:探讨蝙蝠葛酚性碱(PAMD)抗胃癌的作用机理。方法:通过实时定量PCR的方法观察PAMD对胃癌细胞株SGC-7901 Fas mRNA表达的影响,以此探讨PAMD抗肿瘤作用机理。结果::PAMD各剂量组均能上调Fas mRNA的表达,较阳性对照组明显,但差异与空白组比较均不具有统计学意义(P>0.05)。结论:PAMD抗胃癌的作用机理可能与其上调Fas基因表达有关。Objective：To study of Phenolic alkaloids from Menisphermum dauricnm （PAMD） inhibition mechanism of gastric cancer. Methods： By Real - time PCR observation of PAMD on human gastric cancer cell line SGC - 7901 and mRNA expression of Fas, to discuss the antitumor mechanism of PAMD. Results： PAMD groups were able to increase Fas mRNA expression and better than the positive control, but differences compared with the blank group were not statistically significant （ P 〉0. 05 ）. Conclusion： PAMD mechanism against gastric cancer may be associated with increased Fas expression.

关 键 词：蝙蝠葛酚性碱 胃癌 SGC-7901 FAS 

分 类 号：R735[医药卫生—肿瘤]