低氧诱导因子1对中枢神经保护作用的研究进展  

The Research Progress of Central Neuroprotective Effect of Hypoxia-inducible Factor 1

作　　者：刘艳[1] 夏苏英[2] 

机构地区：[1]中南大学湘雅三医院神经内科,长沙410000 [2]长沙市中心医院,长沙市老年医学研究所,长沙410000

出　　处：《医学综述》2014年第8期1348-1350,共3页Medical Recapitulate

基　　金：长沙市科技攻关项目基金(K11011002-31)

摘　　要：低氧诱导因子1(HIF-1)是低氧环境下生成的转录蛋白,具有广泛的下游靶基因。HIF-1除在肾脏、肝脏等脏器的疾病中起着重要作用外,对中枢神经系统也有着显著的保护作用,其机制是通过调节下游靶基因,促进新血管生成、舒张血管、抗细胞凋亡,减轻神经毒性、促进干细胞迁移等。因此,HIF-1成为研究多种疾病治疗方法的热点。Hypoxia-inducible factor 1 （HIF-1） is a transcriptional protein, having many downstream target genes, generated in hypoxia environment. H1F-1 plays an important role in kidney disease and hepaticdisease as well as protection of nervous system. The mechanism of neuroprotective effect is through regulating downstream target genes, which can promote angiogenesis, dialate vessel, strengthen anti-apoptosis, alleviate cytotoxicity, facilitate stem cells migration,and so on. Therefore, HIF-1 has become a new research focus in many diseases.

关 键 词：低氧诱导因子1 神经保护 血管内皮生长因子 促血细胞生成素 

分 类 号：R363[医药卫生—病理学]