调强适形放疗联合放射性^(125)I粒子植入治疗口腔颌面部恶性肿瘤13例疗效观察  

The clinical effect of 13 cases malignant tumor treated by external intensity modulated conformal radiotherapy combined with radioactive ^(125)I particle implanted in oralcavity and maxillofacial

作　　者：胡国志[1] 武英蕾[2] 

机构地区：[1]唐山市工人医院肿瘤放化疗科,河北唐山063000 [2]河北联合大学附属医院麻醉科,河北唐山063000

出　　处：《现代仪器与医疗》2014年第3期60-62,共3页Modern Instruments & Medical Treatment

摘　　要：目的 :评价外放疗联合放射性125I粒子植入治疗口腔颌面部恶性肿瘤的近期疗效和安全性。方法 :选择我院13例口腔颌面部恶性肿瘤患者,依据临床剂量给予患者调强适形放射外治疗和125I放射粒子植入放疗。术后复查并随访,观察并分析患者的疗效、生存状况及不良反应等。结果 :3个月时,9例患者病情得到完全控制,4例部分控制。6个月时,所有患者病灶均完全消退。7个月和14个月时各有1例患者出现转移,经再次治疗得到控制。截止至随访25个月,11名患者依然生存良好,仅1例有复发倾向。整体而言,治疗效果较为理想。结论:外放疗法联合放射性125I粒子植入治疗口腔颌面部恶性肿瘤,疗效明显,可有效控制病灶的发展、降低复发和转移率,具有一定临床推广价值。Objective：To evaluate clinical effect and safety of the treatment by external intensity modulated conformal radiotherapy combined with implant radioactive125I particle for the patients with oral and maxillofacial tumors.Methods： Thirteen patients were objects for the study, and received a combined treatment with external radiotherapy and implant radioactive125I particle, then evaluate the effect, survival and adverse reactions after received treatment.Results：At 3 months, 9 patients’s lesions were control entirely, and 4 patients got a part control for the lesions. At 6 months, the lesions of all patients been controlled completely. One patient occurred relapse, 1 patient occurred lymph node metastasis, the exacerbation was controlled well by received treatment. As to the follow-up about 25 months, 11 patients were still living well, only one patients with recurrent tendencies. Overall, the treatment effect was well.Conclusions： External intensity modulated conformal radiotherapy combined with implant radioactive125I particle could provide a signiifcantly efifcacy for the tumor lesions of the patients above, should be applied in clinical widely.

关 键 词：调强适形放疗 放射性125I粒子 口腔肿瘤 颌面肿瘤 

分 类 号：R739.8[医药卫生—肿瘤]