白细胞介素-18与基质金属蛋白酶-9在蛛网膜下腔出血患者中的动态演变及意义  

Expression and Significance of IL-18 and MMP-9 in Patients with Subarachnoid Hemorrhage

作　　者：刘贵香[1] 张平[1] 张新华[1] 邹伟[1] 

机构地区：[1]南华大学附属南华医院神经内科,湖南省衡阳市421002

出　　处：《医学理论与实践》2014年第10期1261-1262,共2页The Journal of Medical Theory and Practice

摘　　要：目的:探讨白细胞介素-18(IL-18)与基质金属蛋白酶-9(MMP-9)在蛛网膜下腔出血患者中的动态演变及意义。方法:选择29例蛛网膜下腔出血患者作为病例组并按病情及是否发生脑血管痉挛(CVS)分组,选择同期正常健康体检者20例作为对照组,分别于SAH后第1、4、14天采用ELISA法检测血清中IL-18和MMP-9的表达。结果:病例组血清中IL-18和MMP-9表达明显高于对照组(P<0.05),且随着病情恶化,其表达也有升高趋势;SAH患者血清炎症因子在不同时间点CVS组与无CVS组、预后良好组与预后不良组比较,差异有统计学意义(P<0.05)。结论:SAH发生时,患者血清细胞因子的表达明显升高,并且二者表达有密切的关系,共同参与SAH的发生发展。Objective：To investigate the alterations and significances of IL-18and MMP-9in patients with SAH.Methods：29patients with SAH were selected as research object according to the illness and the occurrence of cerebral vasospasm.20health people as control group.The serum IL-18and MMP-9were measured by ELISA on the 1,7,14day. Results：The expression of IL-18and MMP-9in patients with SAH showed significant changes compared with control group（P〈0.05,P〈0.01）.Conclusion：Expression of IL-18and MMP-9were highly increased in the patients with SAH,and they were positively correlated with the severity of inflammation.

关 键 词：蛛网下腔出血 白细胞介素-18(IL-18) 基质金属蛋白酶-9(MMP-9) 预后 

分 类 号：R743.35[医药卫生—神经病学与精神病学]