肝动脉灌注化疗联合Endostar-碘油栓塞治疗原发性肝癌的研究  

Endostar Plus Transcatheter Arterial Chemoembolization(TACE) for Hepatocellular Carcinoma

作　　者：冯岗[1,2,3] 张羽[1,2,3] 王晋[1,2,3] 谢刚[1,2,3] 赵振华[1,2,3] 仁素蓉[1,2,3] 李雪松[1,2,3] 周筱秋[1,2,3] 刘启瑜[1,2,3] 杜小波[1,2,3] 

机构地区：[1]绵阳市中心医院肿瘤科,四川绵阳621000 [2]绵阳市中心医院介入科,四川绵阳621000 [3]绵阳市中心医院病理科,四川绵阳621000

出　　处：《四川医学》2014年第5期566-569,共4页Sichuan Medical Journal

摘　　要：目的探索Endostar用于肝癌介入栓塞的疗效。方法 48例患者分为Endostar组合对照组。所有病例行TACE治疗1～2次,行化疗药物肝动脉灌注,然后对照组用丝裂霉素同碘化油混合物做肝动脉栓塞,在Endostar组使用Endostar同碘化油混合物做动脉栓塞。结果两组患者有不同程度的发热及右上腹疼痛,治疗后两组患者AFP水平、谷丙转氨酶、谷草转氨酶、总胆红素水平、肿瘤体积等指标均明显好于治疗前;且上诉指标在Endostar组能观察到更好的疗效。结论Endostar介入栓塞治疗肝癌未见明显不良反应,而且在肿瘤体积、甲胎蛋白水平、肝功等方面改善更为明显,值得推广应用。Objective To observe the efficacy and safety of Endostar combined with transcatheter arterial chemoembolization（TACE） for treatment of hepatocellular carcinoma patients.Methods A total of 48 patients of hepatocellular carcinoma patients were randomly divided into a Endostar group and a control group.All patients were treated with TACE 1 ～ 2 cycles.The control group patients was treated with chemotherapeutic drugs by transcatheter arterial infusion and then atheroembolism by the admixture of atheroembolism and lipiodol.The Endostar group patients was atheroembolism by the admixture of Endostar and lipiodol.Results All patient got fever and pain at the right upper quadrant.The AFP and liver function of two groups were better than before treatment.The Endostar group was better than the control group.Conclusion Endostar combined with TACE is a safety and effective method for the treatment of hepatocellular carcinoma patient.

关 键 词：肝癌 介入栓 ENDOSTAR 

分 类 号：R735.7[医药卫生—肿瘤]