A型肉毒毒素对脑性瘫痪患儿腘绳肌痉挛的疗效  

Effect of Botulinum Toxin Type A on Spastic Hamstring in Children with Cerebral Palsy

作　　者：刘建军[1,2] 席冰玉[1,2] 纪树荣[1,2] 吴卫红[1,2] 张雁[1,2] 曾凡勇[1,2] 李南玲[1,2] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院,北京市100068

出　　处：《中国康复理论与实践》2014年第5期417-419,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的观察A型肉毒毒素(BTX-A)注射缓解脑瘫患儿腘绳肌痉挛的疗效。方法 39例存在腘绳肌痉挛的脑瘫患儿分为对照组(n=20)和观察组(n=19),对照组采用常规康复训练,观察组在常规康复训练的基础上予BTX-A局部注射。治疗前后采用改良Ashworth量表(MAS)、粗大运动功能测试(GMFM-88)、膝关节屈曲角度进行评定。结果治疗6周后,观察组患儿腘绳肌MAS评分、膝关节屈曲角度、GMFM-88评分均较治疗前改善(P<0.05),且均优于对照组(P<0.05);对照组GMFM-88较治疗前改善(P<0.05)。结论 BTX-A注射可以有效缓解脑瘫患儿腘绳肌痉挛,有助于纠正异常步态,提高患儿运动功能。Objective To observe the effect of Botulinum toxin type A （BTX-A） injection on spastic hamstring in the children with cere-bral palsy. Methods 39 cerebral palsy children with spastic hamstring were divided into control group （n=20） and experimental group （n=19）. The control group accepted physical therapy, while the experimental group accepted BTX-A injection in affected hamstring in addition.They were assessed with modified Ashworth Scale （MAS）, Gross Motor Fucntion Measure （GMFM-88） and flexion angle of knee joints be-fore and after treatment. Results The scores of MAS and GMFM-88, and flexion angle of knee joints improved significantly 6 weeks aftertreatment in the experimental group （P〈0.05）, and improved more than that in the control group （P〈0.05）. Only the score of GMFM-88 im-proved significantly in the control group （P〈0.05）. Conclusion BTX-A injection can relieve hamstring spasticity in children with cerebralpalsy, which may be helpful to correct abnormal gait and improve the motor function.

关 键 词：脑性瘫痪 痉挛 腘绳肌 A型肉毒毒素 步态分析 粗大运动功能 

分 类 号：R742.3[医药卫生—神经病学与精神病学]