膀胱癌病理分级低估的临床分析  

Clinical analysis of underestimation of histology grade in bladder carcinoma

作　　者：王冬彪 卢亮[1] 刘征[1] 苏铁芬[2] 宋晓东[1] 杨为民[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,武汉430030 [2]华中科技大学同济医学院附属同济医院病理外科,武汉430030

出　　处：《现代泌尿生殖肿瘤杂志》2014年第2期79-81,共3页Journal of Contemporary Urologic and Reproductive Oncology

摘　　要：目的探讨膀胱癌病理分级低估现象的可能原因,为膀胱癌患者提供更可靠的病理分级诊断。方法采用WHO2004病理分级标准,对31例先后行膀胱肿瘤电切术和膀胱癌根治术的膀胱癌患者的病理结果进行对比分析。结果 31例患者电切标本病理分级:低度恶性潜能1例、低分级15例、高分级15例;根治术标本病理分级:低度恶性潜能0例、低分级10例、高分级21例。术前术后病理分级一致23例(74.2%),术前分级低估7例(22.6%),高估1例(3.2%)。结论膀胱癌的临床治疗及预后分析中需注意病理分级低估现象,期待分子标志物为膀胱肿瘤病理分级带来变化。Objective To focus on the phenomenon of underestimation in histologic stage in blad-der carcinoma patients in order to provide a more reliable clinical management. Methods 3 1 cases of bladder carcinoma patients were included in the study,the histologic grade of transurethral resec-tion of bladder tumor specimen and cystectomy specimen were compared using WHO2004 patholo-gists classification. Results Among 3 1 patient cases,1 case,1 5 cases,1 5 cases were PUNLMP, low-grade and high-grade in transurethral resection specimen,respectively;while 0 case,10 cases, 21 cases were PUNLMP,low-grade,high-grade in cystectomy specimen,respectively.There were 7 cases （22.6%）of underestimation in the histologic stage,while 1 case （3.2%）of overestimation in the study. Conclusions The clinical treatment and prognosis analysis of bladder carcinoma should consider the underestimation of histologic grade.We are looking forward to new molecular markers that can assist bladder carcinoma grading in the future.

关 键 词：膀胱肿瘤 病理分级 

分 类 号：R737.14[医药卫生—肿瘤]