不同剂量重组人促红细胞生成素治疗恶性肿瘤贫血的疗效观察  

Effects of different doses of recombinant human erythropoietin in the treatment of malignant tumoranemia

作　　者：卢忠[1] 税悦 曾英[3] 

机构地区：[1]四川省宜宾市第一人民医院药剂科,宜宾644000 [2]四川省宜宾市第一人民医院手术室,宜宾644000 [3]四川省宜宾市第一人民医院检验科,宜宾644000

出　　处：《中国肿瘤临床与康复》2014年第5期629-632,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨不同剂量重组人促红细胞生成素治疗恶性肿瘤贫血的疗效,为合理用药提供参考。方法 140例恶性肿瘤贫血患者根据入院顺序分为治疗组和对照组,每组70例。在常规治疗基础上,对照组患者皮下注射重组人促红细胞生成素50IU/kg,治疗组患者注射150 IU/kg,每周3次。两组均治疗8周。结果治疗组患者总有效率为84.3%,对照组患者总有效率为67.1%,两组差异有统计学意义(P<0.05)。两组患者治疗前红细胞压积和血红蛋白水平差异无统计学意义(P>0.05);而治疗后两组组间及组内比较,差异有统计学意义(P<0.05)。与对照组相比治疗组的生理功能、生理功能角色受限、情绪角色受限、活力评分明显较高,差异有统计学意义(P<0.05)。在治疗中,两组患者各出现血压升高2例,使用降压药物后出现好转,差异无统计学意义(P>0.05)。结论大剂量重组人促红细胞生成素治疗恶性肿瘤贫血具有更好的疗效,能提高患者的血红蛋白水平和红细胞压积,改善患者生活质量,安全性较好。Objective To investigate the effects of different doses of recombinant human erythropoietin for treating cancer anemia and provide reference for rational drug use. Methods 140 cases of cancer anemia based on the order of admission were equally divided into the treatment group and the control group, the control group were given subcutaneous recombinant human erythropoietin 50μ/kg, the treatment group were injected with the dose of 150μ/kg, 3 times a week. 8 weeks of treatment in theboth groups. Results The total efficiency of the treatment group and the control group were 84. 3% and 67.1% that there had significant difference compared （ P 〈 0.05 ）. Before treatment, hemoglobin and hematocrit values between the two groups contrasted the difference had not statistically significant, compared with the between- group had statistically significant difference after treatment（ P 〈 0. 05 ）. The physiological function, ole limitations physiological function, emotional role limitations, vitality scores of the treatment group were significantly higher （ P 〈 0. 05 ）. there were 2 patients in each group were high blood pressure and were improved by the use of antihypertensive drugs （ P 〉 0. 05 ）. Conclusion Large doses of recombinant human erythro- poietin for treating cancer anemia has better efficacy and can increase hemoglobin and hematocrit values, improve the quality of life and the safety is better.

关 键 词：恶性肿瘤 贫血 重组人促红细胞生成素 生活质量 

分 类 号：R730.5[医药卫生—肿瘤]