前列地尔注射液对短暂性脑缺血发作脑血流变化的影响  

Effect of alprostadil injection on cerebral blood flow in transient ischemic attack

作　　者：张春驰[1] 董艳娟[1] 何跃[1] 贺昕[1] 

机构地区：[1]北京军区总医院干三科,100700

出　　处：《疑难病杂志》2014年第5期472-473,481,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的探讨前列地尔注射液对短暂性脑缺血发作(TIA)脑血流变化的影响。方法 收集TIA患者121例,随机分为2组,加用前列地尔注射液(治疗组)61例与未加用前列地尔注射液(对照组)60例,治疗前后采用经颅多普勒超声(TCD)检测并对比分析大脑中动脉(MCA)、大脑前动脉(ACA)、双侧椎动脉(VA)及基底动脉(BA)平均血流速度(Vm)的改善,并观察临床疗效。结果 治疗组治愈率、总有效率分别为72.13%、98.36%,明显优于对照组的36.67%、90.00%,差异有统计学意义(P<0.05)。2组治疗前MCA、ACA、VA、BA血流速度比较差异均无统计学意义(P>0.05);治疗后均较治疗前提高(P<0.05,P<0.01),且观察组较对照组提高更显著(P<0.05)。对照组治疗后颈总动脉内径、血流速度、斑块面积无显著改善,治疗组治疗后颈总动脉内径、血流速度显著改善且均优于对照组(P<0.05),而斑块面积亦无显著改善。结论 前列地尔注射液可显著提高TIA患者MCA、ACA、VA、BA血液流速及临床疗效。Objective To investigate the effect of alprostadil injection on cerebral blood flow of transient ischemic attack（TIA）.Methods Collected 121 cases of TIA,they were randomly divided into two groups,alprostadil injection（treatment group） in 61 cases,without the use alprostadil injection（control group） in 60 patients.Before and after treatment,using transcranial Doppler ultrasound（TCD） to detect and comparative analysis of the middle cerebral artery（MCA）,anterior cerebral artery（ACA）,bilateral vertebral artery（VA） and basilar artery（BA） mean velocity（Vm） improvement and clinical efficacy.Results Cure rate and total effective rate were 72.13%,98.36%in treatment group,significandy better than36.67%,90.00%in the control group,the difference was statistically significant（P〈0.05）.Before treatment,MCA,ACA,VA,BA flow velocity difference in the two groups was not statistically significant（P〉0.05）;after treatment,both groups were improved than before treatment（P〈0.05,P〈0.01）,and the observation group improved more significandy than in the control group（P〈0.05）.Control group＇s neck artery diameter,flow velocity,plaque area was not improved significant after uSerapy,the treatment group＇s neck artery diameter,blood flow velocity was significandy improved and were better than the control group（P〈0.05）,while no significant improvement in the plaque area.Conclusion Alprostadil injection can significantly improve the MCA,ACA,VA,BA blood flow and clinical efficacy of TLA.

关 键 词：短暂性脑缺血发作 前列地尔注射液 经颅多普勒超声 脑动脉 

分 类 号：R743.3[医药卫生—神经病学与精神病学]