西红花花瓣粗多糖清除自由基的效果  

Radical Scavenging Activity of Polysaccharides from Petals of Crocus sativus

作　　者：赵成刚[1] 黄一泓[2] 刘雅莉[2] 

机构地区：[1]铜仁学院生物科学与化学系,贵州铜仁554300 [2]华东师范大学生命科学学院,上海200062

出　　处：《湖北农业科学》2014年第4期900-902,919,共4页Hubei Agricultural Sciences

基　　金：贵州省科技厅项目(黔教科2010082)

摘　　要：以研究西红花(Crocus sativus)花瓣粗多糖的体外抗氧化作用为目的,采用化学模拟体系,测定西红花花瓣粗多糖(Polysaccharides from petals of Crocus sativus,PPC)对小鼠血清羟自由基、丙二醛(MDA)、NO和超氧阴离子等的清除能力。结果表明,PPC能抑制脂质过氧化,有效清除血清羟自由基和NO,其IC50分别为0.949、0.079、1.027 mg/mL。PPC能清除一定量的超氧阴离子,并具较强的还原力,且清除能力具有量效关系。To study the antioxidant activity of Polysaccharides from Petals of Crocus sativus（PPC）, scavenging activities and reducing powers of PPC on mice serum ·OH, MDA, O2· and NO were investigated by the chemical simulation system. The results showed that PPC could inhibit lipid peroxidation and effectively remove ·OH and NO. Its IC50were 0.949, 0.079, 1.027 mg / mL. PPC could remove O2· and showed strong reducing power and scavenging activity with dose-effect relationship.

关 键 词：西红花(Crocus sativus)花瓣 粗多糖 自由基 抗氧化作用 

分 类 号：R285[医药卫生—中药学]