乳腺实性乳头状癌临床病理学特征  

Pathological characteristics of solid papillary carcinomas of the breast

作　　者：杨苗苗[1,2] 翁海燕[1,3] 孟刚[1] 

机构地区：[1]安徽医科大学基础医学院病理学教研室,合肥230032 [2]安徽省第二人民医院病理科,合肥230041 [3]安徽省立医院病理科,合肥230001

出　　处：《临床与实验病理学杂志》2014年第5期491-494,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨乳腺实性乳头状癌的临床病理学特征。方法收集9例乳腺实性乳头状癌,行HE及免疫组化染色,根据WHO(2012)乳腺肿瘤标准进行分类。结果 9例乳腺实性乳头状癌中原位实性乳头状癌7例、浸润性实性乳头状癌2例。肿瘤细胞呈多结节状生长,结节呈圆形、类圆形,边缘光滑,可见神经及脂肪组织内浸润。结节内瘤细胞常见假菊形团及细胞核围绕脉管轴心呈栅栏状排列,7例见较明显黏液产生。9例癌组织巢内细胞CK8、ER均弥漫阳性,巢周及巢内肌上皮SMA、p63、CD10均阴性。8例Syn阳性,3例CgA阳性。2例浸润性实性乳头状癌:浸润成分类似浸润性导管癌,但细胞形态类似原位癌,且免疫组化标记Syn阳性。结论乳腺实性乳头状癌呈结节状生长,可见结节浸润神经及脂肪组织内,癌巢周围肌上皮SMA、p63、CD10均阴性。乳腺实性乳头状癌可能是呈推挤性生长的浸润性癌。Purpose To investigate the clinical manifestation, morphologic characteristics and immunophenotypic features of solid papillary carcinomas （SPC） of breast, Methods According to criterion of WHO （2012）, 9 cases of SPC of breast were selected and observed with hematoxylin eosin staining and immunohistochemistry. Results 9 cases of SPC were diagnosed including 7 cases of SPC in situ and 2 cases of invasive SPC. Microscopically, these tumors appeared as multiple nodules. Nodules displayed well-defined pushing borders and invaded fat tissue and nerve. Nuclear palisading around the stromal cores and pseudorosette formation around capillary vessels were also common features. Extraeellular mucin production could also be present in 7 cases. All cases were positive for ER and CK8, negative for SMA, p63, CD10. 8 cases were positive for Syn. 3 cases were positive for CgA. 2 cases were associated with invasive carcinoma. The invasive component had a neuroendocrine-like pattern and was morphologically similar to the adjacent SPC. Conclusion SPC may display nodular, well-defined pushing border and invade fat tissue and nerve. The absence of myoepithelial cells at the periphery of the tumor is confirmed by myoepithelial cell markers. SPC of breast maybe a invasive carcinoma with pushing border.

关 键 词：乳腺肿瘤 实性乳头状癌 病理学特征 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]