松果体实质肿瘤25例临床病理观察  

Pineal parenchymal tumors:a clinicopathologic analysis of 25 cases

作　　者：吴楠[1] 彭李博[1] 吴晋蓉[1] 余波[1] 陆珍凤[1] 马恒辉[1] 石群立[1] 

机构地区：[1]南京军区南京总医院病理科,南京210002

出　　处：《临床与实验病理学杂志》2014年第5期506-510,514,共6页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 观察松果体实质肿瘤（pineal parenchymal tumors,PPTs）的临床病理学特征、免疫表型,探讨其诊断、鉴别诊断、治疗和预后。方法 回顾性分析25例PPTs的临床病理资料、免疫表型等,结合文献分析其临床病理学特征。结果 25例PPTs中,男性14例,女性11例,年龄1.3～63岁,中位年龄42岁。其中,13例为松果体细胞瘤（52%）,4例为中分化松果体实质肿瘤（pineal parenchymal tumors of intermediate differentiation,PPTID）（16%）,8例为松果体母细胞瘤（32%）。结论 PPTs以松果体细胞瘤最常见,多见于成人,其次为松果体母细胞瘤,多发生于婴幼儿及青少年,PPTID最罕见。PPTs确诊依赖病理检查和免疫表型,电镜检查对确诊有一定帮助。肿块完整切除是PPTs适宜的治疗方法。Purpose To investigate the clinicopathologic and immunohistochemical features of pineal parenchymal tumors （PPTs）, and to discuss the diagnosis, differential diagnosis, treatment and prognosis of the tumor. Methods Histopathological characteristics and immunohistochemical results of 25 cases of PPTs were retrospectively studied and the relevant literatures were reviewed. Result 14 patients were male and 11 patients were female, which aged from 2 - 63 with a median of 42 years old. 13 eases were pineocytomas （52%） , 4 cases were pineal parenchymal tumors of intermediate differentiation （PPTID） （ 16% ） , 8 cases were pincoblastomas （ 32% ）. Conchlsion The most common type of PPTs is pineocytoma, which occurs in middle age, followed by pineoblastoma, which occurs primarily in the first two decades of life, and PPTID is rare. The diagnosis of PPTs rely on the histopathology. Immunohistochemical and electronmicroscope results are definite value for diagnosis. The suitable treatment is gross total resection of the tumor.

关 键 词：松果体实质细胞肿瘤 临床病理学 免疫组织化学 治疗 

分 类 号：R739.41[医药卫生—肿瘤]