鼻咽癌初诊患者中耳功能的相关多因素量化分析  

Multiple factors quantitative analysis on middle ear function in primarily diagnosed patients with nasopharyngeal carcinoma

作　　者：陈其国[1,2] 张威[1] 梁勇[1] 刘小龙[1] 陈怀宏[1] 汪琼[2] 赵向东[1,3] 杨村[1] 

机构地区：[1]南方医科大学南方医院耳鼻咽喉-头颈外科,广州510515 [2]深圳市宝安区石岩人民医院耳鼻咽喉-头颈外科 [3]广东省第二人民医院耳鼻咽喉-头颈外科,广州510317

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第10期724-727,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：深圳市宝安区科技计划社会公益项目(No:20110479)

摘　　要：目的:探索量化和客观评价鼻咽癌初诊患者的中耳功能的方法,采用多因素及量化的方法分析其影响因素。方法:对320例(320耳)鼻咽癌初诊患者行电耳镜、声导抗检测、纯音听阈测试、鼻咽部及中耳CT或MRI扫描、咽鼓管功能检查、电子鼻咽镜检查,量化评估中耳功能;采用SPSS 13.0进行单因素及多因素分析。结果:T分期、临床分期、肿物部位、扩散类型、形态、咽鼓管功能及咽口形态、影像学侵犯范围(鼻腔、颅底、咽隐窝、咽旁间隙、腭帆张肌、腭帆提肌)是影响鼻咽癌初诊患者的中耳功能单因素,而性别、年龄、病理类型、N分期、M分期对鼻咽癌初诊患者中耳功能无影响;多因素分析显示:T分期、肿物部位、咽鼓管功能、腭帆张肌侵犯、颅底侵犯是影响鼻咽癌初诊患者中耳功能的独立因素。结论:鼻咽癌初诊患者的中耳功能受T分期、肿物部位、咽鼓管功能、腭帆张肌侵犯、颅底侵犯等相关因素影响,本研究探讨的中耳量化标准能较为客观地评估鼻咽癌初诊患者的中耳功能。Objective：To explore the ways of quantitative and objective evaluation for analyzing the multiple influence factors on middle ear function in the patients with primarily diagnosed NPC, and to analyze the influence factors of middle ear function in the patients with primarily diagnosed nasopharyngeal carcinoma （NPC）. Method： Three hundred and twenty cases （320 ears） of primarily diagnosed NPC patients were examinated with electric otoscope, acoustic immittance measurement , pure tone audiometry, nasopharynx and middle ear CT or MRI scanning,eustachian tube function examination, and electronic nasopharyngoscope. A series of quantitative methods, as the influence factors including T stage, clinical stage, location, diffusion type and form of tumor, eustachian tube function,pharynx mouth shape, imaging extension （nasal, skull base, pharyngeal recess, parapharyngeal space, tensor veli palatini muscle, levator veil palatini and so on）, were used to evaluate the middle ear function. SPSS 13.0 was used to anlyze the single and multiple factors in statistics. Result：T stage, clinical stage, location, diffusion type,and form of tumor, pharynx mouth shape, imaging extension （nasal, skull base, pharyngeal recess, parapharyngeal space, tensor veli palatini muscle, levator veli palatini） were the single influence factors on the function of middle ear in primarily diagnosed NPC patients. The gender, age, pathological types, N staging and M staging of NPC patients primarily diagnosed had no effect on middle ear function. The multple factors analysis showed that T stage, tumor location, the function of eustachian tube, tensor veli palatini muscle invasion, and skull base invasion were independent factor of affecting the middle ear function on primarily diagnosed NPC patients. Conclusion：In this study, the influence factors of middle ear function with primarily diagnosed NPC were related to T stage , location of tumor, the function of eustachian tube, tensor veli palatini muscle invasion, skull base invasio

关 键 词：鼻咽癌 诊断 中耳功能 影响因素 

分 类 号：R739.6[医药卫生—肿瘤]