免疫组化在肺小细胞癌和肺非小细胞癌活检标本中的鉴别诊断价值  

Application of immunohistochemistry in biopsy specimen for differential diagnosis of small cell lung carcinoma and non-small cell lung carcinoma

作　　者：丁岚[1] 姚晨[1] 梅霞[1] 管蕾[1] 姜纯国[2] 吴迎春 

机构地区：[1]扬州市江都人民医院病理科,江苏省扬州225200 [2]首都医科大学附属北京朝阳医院 [3]南京市第二人民医院

出　　处：《中国医师杂志》2014年第4期488-490,共3页Journal of Chinese Physician

摘　　要：目的：探讨免疫组化在肺小细胞癌（SCLC）和肺非小细胞癌（NSCLC）鉴别诊断中的作用。方法应用免疫组化SP法，选择肺穿刺及支气管镜活检标本，病理形态疑似SCLC 共72例，检测CD56、Syn、TTF1、CK5/6、CK14、P63、CK7及NapsinA的蛋白表达，分析SCLC的病理形态特征和免疫表型特点及其与NSCLC的鉴别。结果72例肺癌患者中，SCLC共27例，低分化鳞状细胞癌（SCC）共17例，低分化腺癌（ADC）共28例。结论 SCLC和NSCLC在临床治疗上方法不同，充分应用免疫组化可以进行诊断和鉴别诊断，从而可以减少误诊，同时给临床治疗方案的选择提供重要依据。Objective To investigate the role of immunohistochemistry in the differential diagnosis between small cell lung carcinoma （SCLC） and non-small cell lung carcinoma （NSCLC）.Methods The protein expressions of CD56, Syn, TTF1, CK5/6, CK14, P63, CK7, and NapsinA in percutaneous lung biopsy and bronchoscopic biopsy specimens which were suspected as SCLC were examined by immunohistological streptavidin-peroxidase （ SP） method to analyze the pathological characteristics , immunological pheno-typical features , and differential diagnosis between SCLC and NSCLC .Results Among 72 cases of lung cancer patients ,there were 27 cases of SCLC,17 cases of low differentiated squamous cell carcinoma （ SCC） and 28 cases of low differentiated adenocarcinoma （ ADC） .Conclusions It is the different therapy between SCLC and NSCLC , immunohistochemistry analysis of biopsy can provide ac-curate diagnosis of SCLC and NSCLC , which will result in less misdiagnosis and provide an important valuable in the selection of clini -cal treatment protocols for lung cancer patients .

关 键 词：癌 非小细胞肺 诊断 癌 小细胞 诊断 肺肿瘤 诊断 活组织检查 诊断 鉴别 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]