HIV阳性宫颈癌与HIV阴性宫颈癌的对照分析  

Comparative analysis on HIV- positive cervical cancer and HIV- negative cervical cancer

作　　者：蒋玉娥[1,2] 李灼琴 杨丽[1,2] 胡黎娅[1,2] 

机构地区：[1]昆明医科大学第三附属医院 [2]云南省肿瘤医院检验科,云南昆明650118

出　　处：《中国妇幼保健》2014年第16期2554-2556,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨HIV感染相关性宫颈癌的发病率和一般临床特点。方法：收集2008年4月-2012年3月间住院治疗的全部HIV阳性宫颈癌患者（A组）的临床资料,同时收集2010年3月间连续入院同等数量HIV阴性宫颈癌患者（B组）的临床资料,将两组资料进行对比。结果：两组患者在发病年龄（P=0.038）、T淋巴细胞亚群构成（P=0.000）及全身多发淋巴结肿大发生率（P=0.003）方面均有统计学差异。结论：HIV阳性宫颈癌患者较HIV阴性患者发病更早、T淋巴细胞免疫功能下降、全身多发淋巴结肿大发生率显著增加,提示HIV感染导致免疫功能低下,在HIV阳性宫颈癌发生过程中发挥了重要作用。Objective： To explore the incidence rate and general clinical characteristics of human immunodeficiency virus（ HIV）infection- related cervical cancer. Methods： The clinical data of patients with HIV infection- related cervical cancer（ group A） treated in the hospital from April 2008 to March 2012 were collected; meanwhile,the clinical data of patients with HIV- negative cervical cancer（ group B） treated in the hospital in March 2010 were collected,then the data in the two groups were compared. Results： There were statistically significant differences in onset age（ P = 0. 038）,proportion of T lymphocyte subsets（ P = 0. 000） and incidence rate of total body multiple lymphadenectasis（ P = 0. 003） between the two groups. Conclusion： The patients with HIV infection- related cervical cancer is younger than the patients with HIV- negative cervical cancer,the immunologic function of T lymphocytes decreases,the incidence rate of total body multiple lymphadenectasis increases significantly,which indicate that HIV infection can induce impaired immunity and play an important role in occurrence of HIV infection- related cervical cancer.

关 键 词：HIV 感染 宫颈癌 T淋巴细胞亚群 

分 类 号：R737.33[医药卫生—肿瘤]