宫颈癌高危人乳头瘤病毒型别分布的Meta分析  

The Distribution of High Risk Human Papilloma Virus Types in Cervical Cancer among Chinese Population: A Meta-analysis

作　　者：李寿俊[1] 许国章[2] 易波[2] 陈奕[2] 贺天锋[2] 

机构地区：[1]奉化市疾病预防控制中心,浙江奉化315500 [2]宁波市疾病预防控制中心

出　　处：《浙江预防医学》2014年第5期438-441,共4页Zhejiang Journal of Preventive Medicine

基　　金：浙江省医药卫生平台重点资助计划(2012ZDA041);宁波市重点科技创新团队计划(2012B82018)

摘　　要：目的了解宫颈癌高危人乳头瘤病毒（HR-HPV）型别分布特征。方法系统检索PubMed数据库和《中国期刊全文数据库》收录的2000年1月—2013年1月的文献,摘录相关信息,分别采用直接等权相加和广义倒方差模型进行Meta分析。结果共纳入33篇文献,总HR-HPV感染率为86.41%（95%CI：85.44%～87.38%）,感染率前5位的HPV型别为HPV16、HPV18、HPV58、HPV52和HPV33。广义倒方差模型分析总HR-HPV感染率为86.99%（95%CI：83.45%～90.69%）,纳入的各研究间异质性较大（I2=90.19%,P〈0.05）。引物为SPF10的PCR检测方法检测出的HR-HPV感染率最高,为97.23%（95%CI：96.11%～98.35%）。结论我国妇女宫颈癌中HR-HPV感染型别以HPV16、HPV18、HPV58、HPV52和HPV33为主,不同地区HR-HPV型别分布存在差异。Objective This study aimed to explore the overall prevalence and type distribution of High Risk Human Papilloma Virus（ HR- HPV） in invasive cervical cancer in China. Methods Literatures published on China National Knowledge Infrastructure（ CNKI） and PubMed database from January 2000 to January 2013 were systematically searched. The generic inverse variance model and direct equal- weighted sum model were used. Results 33 studies were included in this meta- analysis. The pooled infectious rate of HR- HPV was 86. 41%（ 95% confidence interval（ CI） 85. 44%-87. 38%）. Top five HR- HPV types in invasive cervical cancer（ ICC） women were HPV16,HPV18,HPV58,HPV52 and HPV33. The generic inverse variance model showed the pooled infectious rate of HR- HPV types was 86. 99%（ 95%CI 83. 45%-90. 69%） with a significant heterogeneity among studies（ I^2= 90. 19%,P〈0. 05）. The infectious rate of HR- HPV in northern China was significantly higher than that in southern China（ P〈0. 05）. Conclusion The main types of HR- HPV infection are HPV16,HPV18,HPV58,HPV52 and HPV33 in China and the distribution varies in regions.

关 键 词：宫颈癌 人乳头瘤病毒 META分析 

分 类 号：R737.33[医药卫生—肿瘤]