头孢曲松钠相关小儿假性胆囊结石的超声表现  

Ultrasonic Manifestation of Pesdolithiasis in Children Associated with Ceftriaxone

作　　者：田晖[1] 刘振通 曹艳梅[1] 徐小丽[1] 赵雅培[1] 剧红娟[1] 王文刚[1] 许文胜[1] 张彤迪[1] 李涛[1] 张丽艳[1] 

机构地区：[1]河北医科大学第二医院超声科,河北省石家庄市050000 [2]河北任丘市人民医院超声科

出　　处：《中国全科医学》2014年第15期1801-1803,共3页Chinese General Practice

摘　　要：目的探讨头孢曲松钠相关小儿假性胆囊结石的超声声像图特征。方法选取2010年1月—2013年3月河北医科大学第二医院超声科收治的胆囊结石患儿45例,采用常规超声检查发现胆囊结石,之前均有静脉滴注头孢曲松钠病史。观察结石类型,记录用药剂量、结石消失时间。结果超声显示胆囊结石泥沙型13例、碎片型13例、团块型9例、混合型10例。头孢曲松钠用量为100 mg/kg者15例、70 mg/kg者17例、50 mg/kg者13例,不同头孢曲松钠用量患儿结石类型间差异有统计学意义（P=0.008）。所有患儿发现结石后即停用头孢曲松钠,停用头孢曲松钠后1-4周结石消失,其中1周内消失8例,2周消失15例,3周消失12例,4周消失10例,不同结石消失时间患儿结石类型间差异无统计学意义（P=0.186）。结论静脉使用头孢曲松钠后小儿易产生假性胆囊结石,停药后对症治疗结石均可在短期内消失,临床医生应正确认识头孢曲松钠会导致胆囊结石产生的不良反应,避免手术进行干预。Objective To study the characteristics of ultrasonic imaging of pseudolithiasis in children associated with ceftriaxone.Methods 45 cases with gallbladder stones scanned by ultrasonography in children who had the history of intravenous of ceftriaxone from January 2010 to March 2013 admitted by ultrasonography in the Second Hospital of Hebei Medical University.The stone types,dosage and the extinction time of stones were observed in this study.Results The ultrasonic images of gallbladder stones showed 13 cases of biliary sludge type,13 cases of debris type,9 cases of block type and 10 cases of mixed type.The dosage of Ceftriaxone：15 cases 100 mg / kg,17 cases 70 mg / kg and 13 cases 50 mg / kg.Significant was noted between ceftriaxone dosage and stone types（P = 0.008）.All cases discontinued ceftriaxone when gallbladder stones were found.All stones disappeared in 45 cases within 4 weeks,among which 8 cases disappeared in 1 week,15 cases in 2 weeks,12 cases in 3 weeks and 10 cases in 4 weeks.Statistical significance was not found between extinction time of cholecystolithiasis and stone types（P =0.186）.Conclusion Intravenous injections of ceftriaxone is likely to result in the pesdolithiasis in children,but the stone after symptomatic treatment can disappear in a short time after withdrawal of ceftriaxone,so the clinical doctors should learn to identify the adverse reaction of cholecystolithiasis cased by ceftriaxone and avoid operation intervention.

关 键 词：头孢曲松 胆囊结石病 儿童 超声检查 

分 类 号：R575.621[医药卫生—消化系统]