核受体NR4A1功能及调控的研究进展  

The research progress in function and regulation of nuclear receptor NR4A1

作　　者：谷亚龙 张新东[1] 金保方[1] 

机构地区：[1]南京中医药大学男科学研究所,210023

出　　处：《中华临床医师杂志（电子版）》2014年第8期87-91,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81273760);国家自然科学基金青年基金(81302969);科技部国家基础规划"973"项目(2010CB530401)

摘　　要：核受体NR4A1是核受体NR4A家族中的重要一员,可通过对靶细胞基因转录的调节,参与细胞的增殖、凋亡调控,在肿瘤发生、血管重塑以及类固醇合成等重要生命活动过程中发挥重要作用,其功能受到磷酸化、蛋白质相互作用等多种途径的调控。本文就有关NR4A1的生物学功能及其调控机理的研究进展作一综述。NR4A1 is an important transcription factor that belongs to NR4A family. NR4A1 plays important roles in numerous cellular responses by regulating the transcription of genes from target cells, including the cell proliferation and apoptosis, tumorigenesis, vascular remodeling and steroidogenic. The function of NR4A1 is regulated by phosphorylation and other interactions among proteins. In this paper, the research progress of NR4A1 in biological function and regulation was reviewed.

关 键 词：细胞增殖 细胞凋亡 NR4A1 类固醇合成 NR4A1 

分 类 号：R363[医药卫生—病理学]