利奈唑胺C环结构改造研究进展  

Recent Developments in Structural Modii cation on Ring C of Linezolid

作　　者：杨月[1] 毕小玲[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009

出　　处：《药学进展》2014年第4期274-278,共5页Progress in Pharmaceutical Sciences

摘　　要：首个噁唑烷酮类抗菌药利奈唑胺自2000年上市以来,其耐药性问题日趋严重,开发新型噁唑烷酮类抗菌药物成为研究热点之一。综述了近年来对利奈唑胺C环进行的结构改造及相关衍生物的研究进展,旨在为噁唑烷酮类抗菌药的深入研发提供参考。Since the first oxazolidinone antibiotic linezolid was marketed in 2000, the problem of its drug resistance has been growing worse. The developments of new oxazolidinone compounds have become a research hotspot. The recent developments in structural modifications on ring C of linezolid and research on the related derivatives were reviewed so as to provide references for the further research and development of oxazolidinone antibiotics.

关 键 词：噁唑烷酮 利奈唑胺 C环 结构修饰 抗菌活性 

分 类 号：R914[医药卫生—药物化学]