癌宁对人胃腺癌细胞SGC-7901细胞因子及Fas基因表达的影响  

CHANGES OF GENES AND CELL FACTORS OF THE HUMAN GASTRIC CANCER CELL SGC-7901 BY AINING.

作　　者：苏勉诚[1] 戴萍[2] 吕晓英[3] 万斌[4] 李红坤[4] 刘继林[4] 

机构地区：[1]珠海丽珠集团国家中药中心,珠海519020 [2]重庆市第三人民医院药剂科 [3]成都军区军事医学研究所 [4]成都中医药大学

出　　处：《现代预防医学》2001年第1期6-7,共2页Modern Preventive Medicine

摘　　要：目的 :探索癌宁对体外人胃癌细胞基因及细胞因子表达的影响。方法 :采用流式细胞术 ,对中药复方癌宁诱导胃癌细胞凋亡机制进行研究。结果 :顺铂、癌宁组与空白对照比较 ,TGF- β1 、Fas和 Fas- L 基因表达产物含量显著增高(P<0 .0 1)。结论 :癌宁对人胃癌细胞的诱导凋亡作用与其对抑癌基因及细胞因子表达的改变有关。Objective:To investigate the effects of Aining on the genes and cell factors of the human gastric cancer cells.Methods:Flow cytometry(FMC) was adopted to explore the inducing apoptosis mechanism of Aining.Rusults:Compared with the blank group,the expression of Fas、Fas-L genes as well as the cell factor TGF-β 1 was high( P< 0 01) in both the Aining group and the cisplatin(DDP) group.Conclusion:The mechanism of inducing the human gastric cancer cells apoptosis by Aining had some relationship with the changes of genes and cell factors.

关 键 词：中药复方 癌宁 基因 细胞因子 胃癌 

分 类 号：R735.202[医药卫生—肿瘤]