神经生长因子对老年痴呆鼠学习记忆能力的影响  

Effect of nerve growth factor on spatial learning and memory in aged rats with unilateral fimbria fornix transection

作　　者：龙大宏[1] 姚志彬[2] 李沃棠[1] 许孟杰[1] 

机构地区：[1]广州医学院解剖学教研室,广东广州510182 [2]中山医科大学解剖学教研室,广东广州510089

出　　处：《中国行为医学科学》2001年第1期4-6,共3页Chinese Journal of Behavioral Medical Science

基　　金：广东省医学科研基金!(编号 :A2 0 0 0 2 5 2 )

摘　　要：目的　探讨神经生长因子 (NGF)对老年痴呆鼠学习记忆能力的影响。方法　切断老年SD大鼠左侧穹窿海马伞(FF) ,侧脑室注射NGF ,用Morris水迷宫和Y迷宫测试正常组、损伤组和治疗组大鼠的学习记忆能力。结果　治疗组大鼠与损伤组相比较 ,治疗组平均逃避潜伏期缩短 ,原平台象限游泳距离和穿环次数增多 ,学会Y迷宫所需训练次数减少和正确反应次数增多 ,但未完全达到正常水平。Objective To study the effect of nerve growth factor on spatial learning and memory in aged rats with unilateral FF transection.Methods Aged male SD rats with left FF lesions received continuous infusion NGF or Cyt.C into the cerebroventricular space.One month after lesion,the learning and memory abilities were measured by Morris water maze and Y maze test.Result NGF treatment group had significantly shortened in escape latency compared with lesioned group.The treatment group had significantly increased compare with lesioned one in the percentage of swim distance in platform quadrant,the number of crossing platform,the number of correct conditioned reflex activity. The treatment group had significantly decreased in number of trial compared with lesioned one.But the parameter of treatment group did not reach the levels of one of normal group.Conclusion It is showed NGF improved the ability of spatial learning and memory in aged rats with FF transection.

关 键 词：神经生长因子 老年性痴呆 学习记忆 老年鼠 

分 类 号：R749.16[医药卫生—神经病学与精神病学]