精神分裂症、神经症、抑郁症患者的脑电超慢涨落图分析  

Analysis of related factors by encephaloflugram technology on patients with schizophrenia,neurosis,depression

作　　者：蒋帅[1] 吴银侠[1] 王大刚[1] 刘光雄[1] 马文涛[1] 杨来启[1] 

机构地区：[1]中国人民解放军第三医院全军精神卫生中心,陕西宝鸡721004

出　　处：《山东医药》2014年第20期1-4,8,共5页Shandong Medical Journal

基　　金：军队中医药科研专项课题(10ZYX108);2012年军区医药卫生科研课题(CWS10JA03CLZ12JB23)

摘　　要：目的：利用脑电超慢涨落图（ EFG）研究门诊0～29岁精神分裂症、神经症、抑郁症患者脑内神经递质、脑功能、各导联熵值的差异。方法采用脑电超慢涨落分析仪，对精神分裂症、神经症、抑郁症患者各检测一次，分析不同疾病、性别的精神疾病患者脑内神经递质、脑功能、各导联熵值的差异。结果精神分裂症患者，乙酰胆碱（Ach）、深抑制递质（INH）显著高于正常值（P均＜0．05），γ-氨基丁酸（GABA）、多巴胺（DA）显著低于正常值（P均＜0．05）。神经症患者，5-羟色胺（5-HT）、Ach显著高于正常值（P均＜0．05）。抑郁症患者，Ach、INH显著高于正常值（P均＜0．05），GABA、NE、DA显著低于正常值（P均＜0．05）。同疾病不同性别的比较发现，精神分裂症男性患者GABA显著低于女性（P＜0．05）。同为男性患不同疾病的比较发现，在GABA和年龄上存在统计学差异（P均＜0．05）。脑功能上，脑缺血缺氧女性抑郁症患者正常比值最少，兴奋和抑制男性神经症患者正常比值最少。不同疾病患者熵值与正常值之间比较发现，三种疾病患者的大脑熵值在正常值范围内且偏高，精神分裂症各导联熵值最高，大脑有序性最差，神经症在大多数导联熵值最低，大脑有序性最好。三种疾病患者的熵值进行方差分析发现，在C4、T4、T5、P4、T6、O1、O2导联存在统计学差异（ P均＜0．05）。同一疾病不同性别患者熵值之间比较发现，精神分裂症在FP1、F8导联男女熵值存在统计学差异（P均＜0．05）。神经症在T6导联男女熵值存在显著性差异（P＜0．05）。同为女性不同疾病患者熵值比较，在F7、C3、C4、T4、T5、P4、T6、O1、O2导联存在统计学差异（P均＜0．05）。结论 GABA功能减低可能是神经精神类疾病的主要原因；女性抑郁症患者伴随缺血缺氧的症状较多，男性神经症患�Objective To observe the differences of neurotransmitters , brain function and entropy values in 0-29 year-old outpatients with schizophrenia , neurosis, and depression by encephaloflugram technology （ETG）.Methods The outpa-tients with schizophrenia , neurosis and depression were tested once by encephaloflugram technology , then the differences be-tween the neurotransmitters , brain function, and entropy values were analyzed .Results The Ach and INH were significantly higher in patients with schizophrenia than the normal （all P〈0.05）, but GABA and DA were significantly below the normal （all P〈0.05）.5-HT and Ach in patients with neurosis were significantly higher than normal （all P〈0.05）.Ach and INH in patients with depression were significantly higher than normal （all P〈0.05）, while GABA, NE and DA were significantly lower than the normal （all P〈0.05）.Comparison between different sexes with the same disease showed that the GABA of male patients with schizophrenia was significantly lower than that of females （P〈0.05）.Comparison between the same men suffering from different diseases showed that significant differences were found in GABA and age （all P〈0.05）.On brain function , the ratio in cerebral ischemia and hypoxia′s normal female patients with depression was the least as well as excitato-ry and inhibitory male patients with neurosis .Comparison between different diseases′entropy and the normal showed that schizophrenia, neurosis, depression′s brain entropy was in the normal range , patients with schizophrenia had maximum entro-py and worst orderly brain , and patients with neurosis had the minimum entropy and the best order .Three diseases′entropy analysis of variance found that there were significant differences in C 4, T4, T5, P4, T6, O1 and O2 leads （all P〈0.05）. Comparison between the different gender entropy values of the same disease found that there were significant difference in FP1 and F8 of patients with schizophrenia between men and women �

关 键 词：精神分裂症 神经症性障碍 抑郁症 神经递质 脑电超慢涨落图 脑功能 熵 

分 类 号：R749[医药卫生—神经病学与精神病学]