通降和胃法治疗胃食管反流病临床效果的meta分析  

Traditional Chinese Medicine Tongjiang Hewei Therapy in Treatment of Patients with Gastroesophageal Reflux Disease: A Meta-analysis

作　　者：孙成宏[1] 陈迪[2] 王斌[3] 

机构地区：[1]解放军白求恩国际和平医院药剂科,石家庄050082 [2]中国中医科学院广安门医院医疗保险办公室,北京100053 [3]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《解放军医药杂志》2014年第5期54-57,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：国家自然科学基金项目(81202858);现代信息科学与网络技术北京市重点实验室开放课题(XDXX1306)

摘　　要：目的：运用meta分析方法系统分析、比较中医与西医治疗胃食管反流病的临床效果。方法收集1990年1月-2014年2月发表的有关中医与西医治疗胃食管反流症随机对照试验的文献,对纳入文献进行质量评价,利用Revman 5.2分析软件对疗效、不良反应进行meta分析。结果本研究共纳入14篇文献,综合Jadad得分2.5~3．0分,包括1703例胃食管反流病。 meta分析结果显示,中医治疗胃食管反流病的效果显著优于西医治疗（合并RR=1.17,95%CI：1.12~1.22,P〈0．01）,但两种疗法不良反应发生率差异无统计学意义（合并RR=0.24,95%CI：0.04~1.52,P〉0．05）。结论中医通降和胃法治疗胃食管反流病的效果显著优于西医治疗,两种疗法安全性相当。Objective To compare the effects of traditional Chinese medicine and western medicine in treatment of gastroesophageal reflux disease （ GERD） using meta analysis. Methods Relevant literature published during January 1990 and February 2014 was randomly selected and evaluated. The meta analysis of efficacy and adverse reactions were performed with RevMan 5. 2 software. Results A total of 14 RCTs （ randomized clinical trial） including 1703 patients with GERD with a score of 2. 5-3. 0 Jadad points, were recruited in this study. The meta-analysis indicated that the effi-cacy of traditional Chinese medicine was significantly better than that of western medicine in treatment of GERD （ com-bined RR= 1. 17, 95% CI：1. 12-1. 22, P〈 0. 01）, but the difference in incidence rate of adverse reactions between traditional Chinese medicine and western medicine was not statistically significant （combined RR= 0. 24, 95% CI：0. 04-1. 52, P〉0. 05）. Conclusion Traditional Chinese medicine of Tongjiang Hewei therapy in treatment of GERD shows bet-ter efficacy compared with that of western medicine treatment, but the two treatments have the similar scores of safety.

关 键 词：胃食管反流病 中医治法 中西医学比较研究 随机对照试验 META分析 

分 类 号：R573.9[医药卫生—消化系统] R195[医药卫生—内科学]