软肝冲剂抗大鼠肝纤维化的实验研究  

EXPERIMENTAL STUDY OF RUANGANCHONGJI ON LIVER FIBROSIS IN RATS

作　　者：姜福义[1,2] 章广玲[1] 

机构地区：[1]河北联合大学,河北唐山063000 [2]承德医学院

出　　处：《承德医学院学报》2014年第3期200-202,共3页Journal of Chengde Medical University

摘　　要：目的:探讨软肝冲剂对大鼠肝纤维化模型的治疗作用。方法:50只雄性Wistar大鼠随机分为正常对照组、模型组、软肝冲剂低剂量组(4g/kg/d)、软肝冲剂高剂量组(8g/kg/d)和鳖甲软肝片组(0.8g/kg/d),每组10只大鼠。40%四氯化碳和40%酒精灌胃制备大鼠肝纤维化模型,各用药组大鼠给予相应药物灌胃8周。分别检测各组大鼠的肝功能,肝纤维化指标层粘连蛋白(LN)、透明质酸(HA)和肝组织羟脯氨酸(HYP)的含量。结果:软肝冲剂可明显改善肝纤维化大鼠模型的肝功能,降低LN、HA和肝组织HYP的含量;并且,软肝冲剂高剂量的效果明显优于软肝冲剂低剂量和鳖甲软肝片。结论:软肝冲剂对肝纤维化大鼠模型具有较好的治疗效果,但具体机制尚待进一步研究。Objective： To explore the therapeutic effects of Ruanganchongji on rat liver ifbrosis model.Methods： 50 male Wistar rats were randomly divided into normal control group, model group, Ruanganchongji low dose group （4g/kg/d）, Ruanganchongji high dose group （8g/kg/d） and Biejiaruanganpian group （0.8g/kg/d）, with 10 rats in each group. The rat liver ifbrosis model was established by lavaging 40% carbon tetrachloride and 40% alcohol; then the rats in each drug group were lavaged with corresponding drugs for 8-week. The liver function, liver ifbrosis indexes （laminin and hyaluronic acid） and hydroxyproline content in liver were respectively detected.Results：Ruanganchongji could improve the liver function of liver ifbrosis rat model; reduce the content of laminin, hyaluronic acid, and hydroxyproline content in liver obviously. Moreover, the effects of Ruanganchongji high dose were better than Ruanganchongji low dose and Biejiaruanganpian.Conclusions：Ruanganchongji has better therapeutic effects on liver ifbrosis model rats, but the mechanisms need further study.

关 键 词：软肝冲剂 肝纤维化 肝功能 羟脯氨酸 

分 类 号：R575.2[医药卫生—消化系统]