PSA 4～10 μg/L患者年龄与前列腺癌检出率及恶性程度的相关性分析  

Correlation of age with detection rate, grade and stage of prostate caner in patients with PSA 4-10 μg/L

作　　者：刘明[1] 侯惠民[1] 苏鸿学[1] 王鑫[1] 王建业[1] 

机构地区：[1]北京医院泌尿外科,100730

出　　处：《中华泌尿外科杂志》2014年第5期346-348,共3页Chinese Journal of Urology

摘　　要：目的 探讨PSA 4～10 μg/L患者的年龄与前列腺癌检出率及肿瘤恶性程度的相关性方法 回顾性分析1997年3月至2010年12月收治的426例PSA 4～10 μg/L患者的资料,根据年龄分为＜60岁组（Ⅰ组,33例）、60～ 69岁组（Ⅱ组,163例）、70～79岁组（Ⅲ组,202例）、≥80岁组（Ⅳ组,28例）.426例均行前列腺穿刺活检,诊断为前列腺癌115例,其中Ⅰ组3例,Ⅱ组32例,Ⅲ组69例,Ⅳ组11例.比较各组年龄与肿瘤检出率的关系,分析各组年龄与Gleason评分及临床分期的相关性. 结果 本组426例中,Ⅰ、Ⅱ、Ⅲ、Ⅳ组的穿刺阳性率分别为9.1％（3/33）、19.6％（32/163）、34.2％ （69/202）、39.3％（11/28）,随着年龄增加,穿刺阳性率逐渐增加,各组间前列腺癌检出率比较差异有统计学意义（Z=4.065 3,P＜0.01）.前列腺穿刺阳性的115例中,Ⅰ、Ⅱ、Ⅲ、Ⅳ组的Gleason评分≥7患者分别为1例（50.0％）、11例（37.9％）、30例（44.8％）、7例（63.6％）,与年龄无显著相关性（P=0.292 4）.Ⅰ、Ⅱ、Ⅲ、Ⅳ组中局限性前列腺癌患者分别为2例（100.0％）、14例（60.9％）、39例（78.0％）、4例（66.7％）;局部进展性前列腺癌分别为0例、5例（21.7％）、7例（14.0％）、1例（16.7％）;转移性前列腺癌分别为0例、4例（17.4％）、4例（8.0％）、1例（16.7％）,各分期与年龄均无显著相关性（P=0.101 6,P=0.285 2,P=0.349 1）. 结论 PSA 4～10 μg/L患者前列腺癌的检出率随着年龄增加而增高,肿瘤恶性程度和转移风险与年龄无明显相关性.Objective To analyze the impact of age on the detection rate,grade and stage of prostate cancer in patients with prostate specific antigen （PSA） 4-10 μg/L.Methods A retrospective analysis was made in 426 patients with PSA 4-10 μg/L who underwent prostate biopsy and divided into 4 group according to their age less than 60 （n=33）,60-69 （n=163）,70-79 （n=202） and more than 80 （n=28） to compare the correlation between age and the cancer detective rate.Among them,115 patients,diagnosed as prostate cancer,were further divided into 4 group according to their age less than 60 （n =3）,60-69 （n=32）,70-79 （n=69） and more than 80 （n=11）.The correlation between age and the Gleason score or clinical stage was analyzed in 115 prostate cancer patients.Results The detective rate in each group was 9.1% （3/33）,19.6% （32/163）,34.2% （69/202） and 39.3% （11/28）.There was significant difference in prostate cancer detective rate among those groups.The cancer detective rate became significantly higher as the age increased （P〈0.001）.In the patients with prostate cancer,the number of patients with Gleason score more than 7 in each group was 1 （50.0%）,11 （37.9%）,30 （44.8%）,7 （63.6%）.No significant correlation was found between age and grade （P=0.292 4）.And each group had cases with localized prostate cancer was 2 （100.0%）,14 （60.9%）,39 （78.0%）,4 （66.7%）,with locally advanced prostate cancer 0,5 （21.7%）,7 （14.0%）,1 （16.7%）,with metastatic prostate cancer 0,4 （17.4%）,4（8.0%）,1 （16.7%）.No significant difference was found between each group and clinical stage （P =0.101 6,P=0.285 2,P=0.349 1）.Conclusions The prostate cancer detective rate significantly increases with the age increasing.There is no significant correlation between age and grade or clinical stage in the patients with PSA 4-10 μg/L.

关 键 词：前列腺肿瘤 前列腺特异性抗原 年龄 相关性 

分 类 号：R737.25[医药卫生—肿瘤]