酰基吡唑啉酮与聚吡咯修饰玻碳电极电化学氧化氧氟沙星的行为  

Electrochemical Oxidation Behavior of Ofloxacin Based on Acylpyrazolone/ Polypyrrole Glassy Carbon Modified Electrode

作　　者：刘阳[1] 李锦州[1] 张慧慧[1] 

机构地区：[1]哈尔滨师范大学化学化工学院,黑龙江哈尔滨150025

出　　处：《化学与粘合》2014年第3期173-176,共4页Chemistry and Adhesion

基　　金：黑龙江省自然科学基金项目(编号:201004)

摘　　要：制得一种复合膜修饰玻碳电极HPMαFP/Ppy/GCE（HPMαFP：1-苯基-3-甲基-4-（α-呋喃甲酰基）-5-吡唑啉酮，/Ppy：聚吡咯, GCE：玻碳电极）。通过循环伏安法（CV）和脉冲伏安法（DPV）研究了氧氟沙星（OFL）在电极上的电化学行为。该修饰电极显现特定的测定氧化峰电流和高检测灵敏度。在pH=7,扫速为100mV·s-1的条件下，测试OFL的CV曲线于Ep=0.88 V出现一不可逆的氧化峰。氧化峰电流与OFL浓度在2.0×10-6 1.0×10-4mol·L-1范围内呈良好的线性关系。检出限为6.5×10-8mol·L-1。A new composite film modified electrode HPMαFP/Ppy/GC （HPMαFP：1-phenyl-3-methyl-4-（α-furoyl）-5-pyrazolone, Ppy：polypyrrole, GCE：glassy carbon electrode） was developed for determination of ofloxacin（OFL）. The electrochemical behavior of OFL on the electrode was investigated by cyclic voltammetry （CV） and differential pulse voltammetry （DPV）. The HPMαFP/Ppy/GCE showed a specific oxidation peak current and a good detection sensitivity. Under the condition of pH=7, an irreversible oxidation peak of OFL with Ep=0.88V was obtained on the modified electrode with a scan rate of 100 mV·s-1. There was a good linear relation between oxidation peak current and concentration of OFL in the range of 2×10-6~1×10-4 mol·L-1. And the detection limit was 6.5×10-8 mol·L-1.

关 键 词：酰基吡唑啉酮 聚吡咯 氧氟沙星 修饰电极 

分 类 号：TQ927.2[轻工技术与工程—发酵工程]