葡萄糖调节蛋白78在卵巢癌组织中的表达及临床意义  

Expression of glucose-regulated protein 78 in ovarian cancer tissues and its clinical significance

作　　者：张丽颖[1] 徐爱丽[1] 原丹丹[1] 艾丽敏 李佩玲[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,150086 [2]哈尔滨解放军第九三二二○部队门诊部,150086

出　　处：《中国医师进修杂志》2014年第15期1-3,共3页Chinese Journal of Postgraduates of Medicine

基　　金：黑龙江省青年科学基金（QC2009C82）;黑龙江省博士后科研启动金（LBH-Q11051）;黑龙江省卫生厅科研课题（2007-320）

摘　　要：目的 探讨葡萄糖调节蛋白（Grp）78在卵巢癌组织中的表达及临床意义.方法 采用免疫组织化学法检测60例卵巢癌组织、15例卵巢交界性肿瘤组织、10例正常卵巢组织、10例卵巢囊肿组织Grp78阳性表达情况,分析其表达与卵巢癌临床特征的关系.结果 卵巢交界性肿瘤和卵巢癌组织中Grp78阳性表达率明显高于正常卵巢和卵巢囊肿组织[7/15和68.3％（41/60）比1/10和1/10],差异有统计学意义（P＜0.05）.Grp78表达与卵巢癌临床分期和淋巴结转移呈正相关（P＜0.05）,与分化程度呈负相关（P＜0.05）,与年龄及腹水无相关性（P＞0.05）.结论 卵巢癌组织中Grp78表达呈增高趋势;Grp78的高表达可能与卵巢癌的发生、发展及预后有重要联系.Grp78表达可作为判定卵巢癌发生及淋巴转移能力的一项有效客观指标.Objective To explore the expression of glucose-regulated protein （Grp） 78 in ovarian cancer tissues and its clinical significance.Methods The expression of Grp78 in 60 cases of ovarian cancer tissue,15 cases of ovarian borderline tumor tissue,10 cases of normal ovarian tissue,10 cases of ovarian cyst tissue,was detected by immunohistochemistry,and analyzed the relationship between its expression and clinicopathological features of ovarian cancer.Results The expression of Grp78 in ovarian borderline tumor and ovarian cancer tissue was significantly higher than that in normal ovarian and ovarian cyst tissue[7/15 and 68.3% （41/60） vs.1/10 and 1/10] （P 〈0.05）.The expression of Grp78 was positively correlated with clinicopathological staging and lymphatic metastasis of ovarian cancer （P 〈 0.05）,negatively correlated with histological differentiation （P 〈 0.05）.No correlation with age and ascites （P 〉 0.05）.Conclusions The levels of Grp78 are elevated in ovarian cancer specimens; high expression of Grp78 maybe participate in the occurrence,development,and prognosis of ovarian cancer.Increased expression of Grp78 might be a useful marker for predicting the carcinogenesis and progression of ovarian cancer.

关 键 词：卵巢肿瘤 葡萄糖调节蛋白 

分 类 号：R737.31[医药卫生—肿瘤]