共刺激分子B7-CD_(28)在肿瘤免疫研究中的进展  

Progress of costimulatory molecules B7-CD_(28) in tumor immunity

作　　者：杨露[1] 孙宏伟[2] 柳星[2] 秦宝丽[2] 

机构地区：[1]大连医科大学,七年制116044 [2]辽宁省肿瘤医院内二科

出　　处：《中国实用医药》2014年第11期247-248,共2页China Practical Medicine

摘　　要：抗肿瘤免疫以细胞免疫为主,共刺激分子发挥了相当重要的作用。B7-CD28是激发机体抗肿瘤免疫应答的共刺激信号,由于肿瘤细胞缺乏B7分子的表达,机体抗肿瘤作用显著降低。转基因治疗后,可以使机体重新获得对肿瘤的主动免疫应答能力。Costimulatory molecules play a vital role of cell-mediated immunity, which is main component of anti-tumor immunity. As one kind of costimulatory molecules, B7-CD28 is to stimulate anti-tumor immune response. Due to lack of expression of B7-CD28 molecules in tumor cells, the body’s anti-tumor effect was significantly reduced. Then the body would regain active immune response capability after gene therapy re-expressed B7-CD28 in tumor cells.

关 键 词：共刺激分子 B7-CD28 肿瘤免疫 基因治疗 B7-CD28 

分 类 号：R730.3[医药卫生—肿瘤]