脑胶质瘤术后放疗的长期治疗结果和预后179例分析  

Long-term treatment outcome and prognostic factors analysis of 179 cases of brain glioma treated with post-operative radiotherapy

作　　者：詹益州[1] 谢良喜[1] 史永义[1] 谢文佳[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院放疗科,515031

出　　处：《山西医药杂志》2014年第10期1099-1101,共3页Shanxi Medical Journal

基　　金：国家自然科学基金(81171994)

摘　　要：目的报告脑胶质瘤放疗长期生存结果,分析预后影响因素。方法回顾性分析1999年11月至2009年10月在我科行放疗的179例脑胶质瘤患者长期治疗结果,Kaplan-Meier法行生存分析,Log-rank检验行单因素分析,Cox回归模型行多因素分析。结果全组中位生存期26个月,1、3、5、10年的总生存率分别为69.3%、43.0%、36.8%和26.2%;单因素分析显示：年龄〉40岁（P=0.008）、世界卫生组织（WHO）中枢神经系统肿瘤病理分级Ⅲ~Ⅳ级（P〈0.01）、卡氏评分〈80（P=0.043）患者均预后不良;多因素分析显示：年龄〉40岁（RR=6.283,95%CI：1.108~2.344,P=0.013）、WHOⅢ~Ⅳ级（RR=19.707,95%CI：1.603~3.380,P〈0.01）是预后不良独立影响因素。结论年龄、病理分级是影响脑胶质瘤术后放疗的独立预后因素。Objective To report the long-term treatment outcome and to explore the prognostic factors for brain glioma treated with post-operative radiotherapy .Methods One hundred and seventy nine cases of brain glio-ma treated with postoperative radiotherapy in our department from November 1999 to October 2009 were retro-spectively analyzed .Kaplan-Meier method was used to calculate the survival rate ,Log-rank test was used for uni-variate analysis .Cox proportional hazard model was used for multivariate analysis .Results The median survival time was 26 months for whole group .1 ,3 ,5 and 10 year survival rate were 69 .3% ,43.0% ,36.8% and 26.2% , respectively .Univariate analysis showed that age〈40 years （ P =0.008） ,WHO central nervous system tumor grade Ⅲ-Ⅳ （ P〈0.01） and Karnofsky performance〈80（ P=0.043） were significant prognostic factors .Multi-variate analysis showed that age＆gt;40 years （ RR =6 .283 ,95% CI ：1.108~2.344 ,P =0 .013） and WHO gradeⅢ-Ⅳ（ RR =19.707 ,95% CI ：1.603~3.380 ,P＆lt;0.01） were independent adverse prognostic factors .Conclusion Age and pathological grade are independent adverse prognostic factors for patient with brain glioma treated with post-operative radiotherapy.

关 键 词：肿瘤 放射疗法 预后 

分 类 号：R739.41[医药卫生—肿瘤]