RNA干扰技术与眼科疾病  

RNA interference technology and Ophthalmic diseases

作　　者：秦贤杰[1] 彭燕一[2] 

机构地区：[1]桂林医学院,中国广西壮族自治区桂林市541004 [2]桂林医学院附属医院眼科,中国广西壮族自治区桂林市541001

出　　处：《国际眼科杂志》2014年第5期849-851,共3页International Eye Science

摘　　要：RNA干扰(RNA interference,RNAi)是近年来生物学研究领域的一项重大发现,是由双链RNA诱导的特异性序列的基因沉默现象。近年来,RNAi技术日益完善、成熟,已逐渐应用于功能基因组学、基因表达调控机制等研究领域。作为一种有效的工具,RNAi技术在眼科疾病的基因治疗方面也取得了很大的进展。本文就近年来国内外关于RNAi技术与角膜内皮细胞损伤、白内障、青光眼、新生血管性疾病、增生性玻璃体视网膜病变的研究现状进行简要概括。RNA interference is an important discovery in the field of biology in recent years, which is a gene silencing phenomena of specific sequences induced by double-stranded RNA. RNAi technology becomes perfect and mature increasingly, and has been gradually applied in functional genomics, regulatory mechanisms of gene expression research areas. As an effective tool, RNAi technology in gene therapy of eye disease has also made great progress. This paper briefly reviews the current researches of RNAi technology adopting in corneal endolthelial cells injury and therapies of cataract, glaucoma, neovascular diseases and proliferative vitreoretinopathy.

关 键 词：RNAI技术 角膜内皮细胞损伤 白内障 青光眼 新生血管性疾病 增生性玻璃体视网膜病变 

分 类 号：R77[医药卫生—眼科]