翼状胬肉切除联合带自体角膜缘干细胞的结膜移植治疗复发性翼状胬肉  

Clinical effects research of the excision of pterygium combined with limbal epithelial autograft with conjunctival grafting on recurrent pterygium

作　　者：范惠雅[1] 陈子林[1] 宋青山[1] 

机构地区：[1]中国广东省惠州市中心人民医院眼科,516000

出　　处：《国际眼科杂志》2014年第5期961-963,共3页International Eye Science

基　　金：2012年广东省惠州市科技计划项目(No.2012Y035)~~

摘　　要：目的:观察翼状胬肉切除联合带自体角膜缘干细胞的结膜移植治疗复发性翼状胬肉的临床疗效。方法:复发性翼状胬肉患者84例,随机分为两组,研究组(43例43眼)行翼状胬肉切除联合带自体角膜缘干细胞的结膜移植术;对照组(41例41眼)行翼状胬肉切除联合自体结膜移植术。术后随访12mo,观察角膜上皮愈合时间、术后1,3mo行泪膜破裂时间(BUT)、泪液分泌试验(SⅠt试验)、角膜荧光染色检查(FL)、复发率,评价其临床疗效。结果:研究组比对照组术后角膜上皮愈合时间短、复发率低(P<0.05),但在术后1mo及3mo的BUT,SⅠt试验,FL方面并无优越性(P>0.05)。结论:翼状胬肉切除联合带自体角膜缘干细胞的结膜移植是治疗复发性翼状胬肉的一种方便、安全、有效的方法。AIM： To observe the clinical effects of the excision of pterygium combined with limbal epithelial autograft with conjunctival grafting on recurrent pterygium. METHODS： Totally 84 patients （ 84 eyes ） with first recurrent pterygium were allocated two groups： excision pterygium with limbal epithelial autograft with conjunctival（ group A, 43 cases with 43 eyes） and excision of pterygium with conjunctival autograft （ group B, 41 cases with 41 eyes） , the post-operative follow-up period of 12 months, we analyzed the repair time of epithelium, tear break-up time （ 1 month and 3 months ） , Schirmer l test （ 1 month and 3 months ） , corneal fluorescence staining test（1 month and 3 months）, and recurrent rate. RESULTS： The group A had a shorter repair time of epithelium and lower recurrent rate, compared with the group B, which had statistically significant difference （ P〈0. 05）, but there was no statistically significant difference in the tear break-up time, corneal fluorescence staining test and the Schirmer l test in 1 month and 3 months between the two groups（P〈gt;0. 05）. CONCLUSION： Limbal epithelial autograft with conjunctival transplantation is a convenient, safe, effective method for the treatment of recurrent pterygium.

关 键 词：干细胞 移植 复发性翼状胬肉 疗效 

分 类 号：R779.6[医药卫生—眼科]