肝动脉化疗栓塞联合经皮射频治疗老年中晚期肝癌的疗效  

Efficacy of transcatheter arterial chemoembolization combined with radiofrequency ablation in treatment of elderly patients with advanced hepatocellular carcinoma

作　　者：李志强[1] 孙海[1] 邓小明[1] 张丰深[1] 

机构地区：[1]重庆市江北区解放军324医院肝胆外科,重庆400020

出　　处：《胃肠病学和肝病学杂志》2014年第5期494-496,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的分析肝动脉化疗栓塞(TACE)联合经皮射频消融(RFA)治疗老年中晚期原发性肝癌(HCC)的疗效,为HCC的临床治疗提供参考。方法按照随机数字表法将80例患者分为TACE联合RFA治疗组(观察组)和RFA治疗组(对照组),比较两组治疗效果。结果观察组肿瘤瘤体缩小率高于对照组,两组比较,差异具有统计学意义(P<0.05);甲胎蛋白下降超过50%者,观察组(85.7%)与对照组(55.6%)比较差异具有统计学意义(P<0.05)。两组不良反应发生情况差异无统计学意义(P>0.05);术后24个月随访,观察组生存率27例(67.5%),对照组生存率17例(42.5%),两组比较差异具有统计学意义(P<0.05)。结论 HCC患者对TACE联合RFA治疗的耐受性较好,联合治疗的安全性和可行性较好。Objective To analyze the efficacy of transcatheter arterial chemoembolization （TACE） combined with percutaneous radiofrequency ablation （RFA） in treatment of elderly patients with hepatocellular carcinoma （HCC）,and to provide reference for the treatment of patients with HCC.Methods According to the random number table,80 patients were divided into the TACE combined with RFA treatment group （the observation group） and the RFA treatment group （the control group）.The efficacy was compared between two groups.Results The tumor regression rate of the observation group was higher than that of the control group （P ＜0.05）.The AFP declined by more than 50％ of the observation group （85.7％） was significantly higher than that of the control group （55.6％）.There was no statistically significant difference in the incidence of adverse reactions between two groups （P ＞ 0.05）.After 24 months＇ follow-up,the survival rate of the observation group was 67.5％,which was significant higher than that of the control group （17 cases,42.5％） （P ＜ 0.05）.Conclusion The TACE combined with RFA in treatment of elderly patients with HCC is safe and feaible.

关 键 词：肝癌 肝动脉化疗栓塞 经皮射频 疗效 

分 类 号：R735.7[医药卫生—肿瘤]