左卡尼汀治疗非酒精性脂肪肝32例胰岛素抵抗变化  

The effect of L-carnitine on insulin resistance of 32 cases with nonalcoholic fatty liver

作　　者：张晓红[1] 田怡[1] 刘启平[1] 贝颂华 刘建生[1] 

机构地区：[1]上海瑞金医院集团闵行区中心医院消化内科,上海201199

出　　处：《蚌埠医学院学报》2014年第5期585-586,589,共3页Journal of Bengbu Medical College

基　　金：上海市闵行区自然科学研究资助课题(2010MHZ039)

摘　　要：目的:探讨左卡尼汀(LC)治疗非酒精性脂肪肝(NAFLD)的疗效。方法:62例NAFLD患者,随机分为LC治疗组(LC组)32例和安慰剂对照组30例,LC组予LC口服,每次1 g,早晚饭后各1次,疗程共24周。记录治疗前后患者血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、三酰甘油(TG)、总胆固醇(TC)、C反应蛋白(CRP)、空腹血糖(FBG)、胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平,以及肝脏超声表现。结果:与治疗前和对照组比较,LC组治疗后ALT、AST、GGT、TG,TC、FINS、HOMA-IR值均明显降低(P<0.01),肝脏B超明显改善,总有效率明显高于对照组(P<0.01)。结论:左卡尼汀可有效改善NAFLD患者肝功能、血脂,减轻胰岛素抵抗,能安全有效地用于治疗NAFLD。Objective： To explore of the effects of L-carnitine（ LC） in the treatment of nonalcoholic fatty liver disease（ NAFLD）.Methods： Sixty-two patients with NAFLD were randomly divided into the LC treatment group（ LC group）（ 32 cases） and placebo control group（ 30 cases）. The LC group were treated with 1 g of LC by oral,twice a day for 24 weeks after breakfast and dinner. The levels of serum alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,γ-glutamyltransferase（ GGT）,triglyceride（ TG）,total cholesterol（ TC）,C reactive protein（ CRP）,fasting plasma glucose（ FBG）,insulin（ FINS）,insulin resistance index（ HOMA-IR）and liver ultrasound in all patients were recorded before and after treatment. Results： Compared with the before treatment and control group,the levels of ALT,AST and GGT,TG and the TC,FINS and HOMA-IR of LC group decreased significantly（ P〈0. 01）,and the liver B ultrasound was improved obviously after treatment. The total effective rate of the LC group was significantly higher than that in control group（ P〈0. 01）. Conclusions： L-carnitine can effectively improve the liver function and blood lipid,and reduce the insulin resistance of patients with NAFLD,which is a safe and effective drug in the treatment of NAFLD.

关 键 词：脂肪肝 非酒精性 左卡尼汀 胰岛素抵抗 

分 类 号：R575[医药卫生—消化系统]