安妥沙星治疗自发性腹膜炎的疗效和安全性观察  

Antofloxacin for the treatment of spontaneous bacterial peritonitis

作　　者：孙学强[1] 张晨光[1] 毛志方[1] 

机构地区：[1]蚌埠医学院第二附属医院感染科,安徽蚌埠233040

出　　处：《蚌埠医学院学报》2014年第5期593-596,共4页Journal of Bengbu Medical College

摘　　要：目的:观察安妥沙星对社区获得非复杂性肝硬化自发性腹膜炎的疗效和治疗安全性。方法:51例自发性腹膜炎患者均为社区获得、非复杂性肝硬化患者,随机分为观察组24例和对照组27例,其中对照组静脉使用头孢噻肟每次2 g,每天2次,共10 d;观察组口服安妥沙星片,首日1次400 mg,以后9 d每天1次200 mg。结果:观察组口服安妥沙星片10 d后丙氨酸氨基转移酶和总胆红素均较治疗前降低(P<0.05),白蛋白较治疗前升高(P<0.01),而肌酐和凝血酶原时间均无明显变化(P>0.05),QT间期无延长,2组治疗有效率差异无统计学意义(P>0.05)。结论:口服安妥沙星治疗非复杂性肝硬化自发性腹膜炎安全有效。Objective： To evaluate the efficacy and safety of antofloxacin in the treatment of community-acquired uncomplicated spontaneous bacterial peritonitis（ SBP） infection. Methods： Fifty-one cirrhotic patients with community-acquired uncomplicated SBP were divided into observation group（ n = 24） and control group（ n = 27）. The control group received cefotaxime 2 g intravenously2 times a day for 10 days and the observation group were given antofloxacin 400 mg orally once on the first day,then 200 mg in the following 9 days. Results： After 10 days therapy,the observation group manifested a decrease in alanine amino transferase and total bilirubin（ P〈 0. 05）,an increase in albumin（ P〈0. 01）,no significant changes in creatinine and prothrombin time（ P〉 0. 05）,and no extension in QT intervals. The total effective rates had no statistical significance between the two groups（ P 〉0. 05）. Conclusions： Oral administration of antofloxacin is effective and safe for treatment of community-acquired uncomplicated SBP.

关 键 词：腹膜炎 安妥沙星 头孢噻肟 

分 类 号：R572.2[医药卫生—消化系统]