食管鳞状细胞癌组织中 E-钙粘蛋白的表达和临床意义  

Expression of E- Cadherin in human esophageal squamous cell carcinoma and its clinical signifi-cance

作　　者：王瑾[1] 张昭[1] 乔俊静[1] 别亚男[1] 秦艳茹[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科, 450052

出　　处：《中国实用医刊》2014年第12期1-4,共4页Chinese Journal of Practical Medicine

基　　金：河南省卫生厅基金资助项目（2011020021）;河南省科技厅基金资助项目（112102310618）

摘　　要：目的：探讨食管鳞状细胞癌组织中 E-钙粘蛋白的表达情况，并分析其与食管鳞状细胞癌的临床病理及5年生存率的关系。方法233例患者均来自河南省林州市。利用组织微阵列技术，采用免疫组化 ABC 法，分析233例食管鳞癌组织（观察组）和相应正常黏膜组织（对照组）中 E-钙粘蛋白表达情况。结果食管鳞癌组织中 E-钙粘蛋白的低表达阳性率高于正常食管黏膜组织中低表达阳性率（56.22% vs 39.29%，P 〈0.05）；食管鳞癌组织中 E-钙粘蛋白的低表达与食管鳞癌的淋巴结转移、TNM 分期有关，与食管鳞癌的发病年龄、性别、癌细胞分化程度、癌组织大体类型无关；E-钙粘蛋白正常表达的食管鳞癌患者5年生存率明显高于 E-钙粘蛋白低表达的食管鳞癌患者。结论 E-钙粘蛋白的低表达可能与食管鳞癌的发生、发展、转移相关，检测 E-钙粘蛋白可能为判断食管鳞癌的预后提供参考依据。Objective To investigate the role of E-Cadherin,in the development and progres-sion of human esophageal squamous cell carcinoma（ESCC）,and its relationship with the clinicopatho-logic characteristics and five-year survival rate of the patients. Methods The expression levels of E-Cadherin were detected in 233 ESCC tissues and their corresponding normal esophageal mucosal tissues by tissue array and immunohistochemistry. Results ESCC tissues showed a significantly higher low ex-pression rate of E-Cadherin than their corresponding normal esophageal mucosal tissues（56. 22% vs 39. 29% ,P 〈 0. 05）. The low expression of E-Cadherin was correlated with lymph node metastasis and TMN stage,but not with the patients’age,gender,tumor differentiation and general classification. Sur-vival analysis showed that abnormal expression of E-Cadherin was correlated with the 5-year survival rate of patients with ESCC. Conclusions The abnormal expression of E-Cadherin may play an important role in the progression of ESCC,and detection of E-Cadherin expression may have important prognostic value.

关 键 词：E-钙粘蛋白 食管鳞状细胞癌 组织芯片 5 年生存率 

分 类 号：R735.1[医药卫生—肿瘤]